Evidence map›Paper›PMID 31662709›Full record

ReviewDose-response : a publication of International Hormesis Society

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects.

Xiaoxiang He, Jingyao Sun, Jian Zhuang, Hong Xu, Ying Liu, Daming Wu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 140 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiaoxiang HeCollege of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, China.
Jingyao SunCollege of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, China.ORCID https://orcid.org/0000-0002-0140-0212
Jian ZhuangCollege of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, China.
Hong XuCollege of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, China.
Ying LiuState Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, China.
Daming WuCollege of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, China.
Beijing University of Chemical Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microneedle (MN) delivery system has been greatly developed to deliver drugs into the skin painlessly, noninvasively, and safety. In the past several decades, various types of MNs have been developed by the newer producing techniques. Briefly, as for the morphologically, MNs can be classified into solid, coated, dissolved, and hollow MN, based on the transdermal drug delivery methods of "poke and patch," "coat and poke," "poke and release," and "poke and flow," respectively. Microneedles also have other characteristics based on the materials and structures. In addition, various manufacturing techniques have been well-developed based on the materials. In this review, the materials, structures, morphologies, and fabricating methods of MNs are summarized. A separate part of the review is used to illustrate the application of MNs to deliver vaccine, insulin, lidocaine, aspirin, and other drugs. Finally, the review ends up with a perspective on the challenges in research and development of MNs, envisioning the future development of MNs as the next generation of drug delivery system.

Indexed as

drug delivery methodsfabricating methodsmaterialsmicroneedlestructurestransdermal drug delivery

Identifiers

PMID31662709
PMCPMC6794664
OpenAlexW2980747750

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.