Evidence map›Paper›PMID 31662517›Full record

ArticleIn vivo (Athens, Greece)

Excessive Expression of Microglia/Macrophage and Proinflammatory Mediators in Olfactory Bulb and Olfactory Dysfunction After Stroke.

Chien-Fu Yeh, Tung-Yueh Chuang, Ming-Ying Lan, Yu-Ching Chin, Wei-Hsin Wang, Yung-Yang Lin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chien-Fu YehDepartment of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
Tung-Yueh ChuangDepartment of Critical Care Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
Ming-Ying LanDepartment of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
Yu-Ching ChinDepartment of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
Wei-Hsin WangDepartment of Neurosurgery, Taipei Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.
Yung-Yang LinInstitute of Brain Science, National Yang-Ming University, Taipei, Taiwan, R.O.C. yylin@vghtpe.gov.tw.
National Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimOlfactory dysfunction can be caused by stroke but the pathogenesis is still unclear. Previous studies have proved that olfactory dysfunction could be caused by microglia activation in the olfactory bulb and that middle cerebral artery occlusion (MCAO) may induce ipsilateral olfactory bulb microglia activation. This study aimed to explore the possible pathogenesis of ischemic stroke-induced olfactory dysfunction. MATERIALS AND

methodsWe used a rat model of MCAO to simulate ischemic stroke. Olfactory function tests were performed using buried food test. The mRNA expression of olfactory marker protein (OMP), microglia/macrophage activation, and proinflammatory mediators were measured using reverse transcription-quantitative polymerase chain reaction.

resultsFollowing MCAO, rats had poorer olfactory performance. In the olfactory bulb of the rats, the mRNA expression of OMP decreased and the mRNA expression of microglia/macrophage activation and proinflammatory mediators increased.

conclusionIschemic stroke causes microglia/macrophage activation and promotes neuroinflammation in the olfactory bulb, causing olfactory dysfunction.

Indexed as

AnimalsCytokinesDisease Models, AnimalFemaleInfarction, Middle Cerebral ArteryInflammationMacrophagesMaleMicrogliaOlfactory BulbOlfactory Marker ProteinRatsRats, Inbred WKYRNA, MessengerStrokeCytokinesOlfactory Marker ProteinRNA, Messengerischemic strokemacrophagemicrogliamiddle cerebral artery occlusionOlfactory dysfunctionproinflammatory mediatorrat

Identifiers

PMID31662517
PMCPMC6899110
OpenAlexW2988036987

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.