Evidence map›Paper›PMID 31662513›Full record

ArticleIn vivo (Athens, Greece)

Effects of Photosensitization of Curcumin in Human Glioblastoma Multiforme Cells.

Aleksander Kielbik, Piotr Wawryka, Dawid Przystupski, Joanna Rossowska, Anna Szewczyk, Jolanta Saczko, Julita Kulbacka, Agnieszka Chwiłkowska

Open access · diamondAbstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Aleksander KielbikFaculty of Medicine, Wroclaw Medical University, Wroclaw, Poland.
Piotr WawrykaFaculty of Medicine, Wroclaw Medical University, Wroclaw, Poland.
Dawid PrzystupskiFaculty of Medicine, Wroclaw Medical University, Wroclaw, Poland.
Joanna RossowskaInstitute of Immunology and Experimental Therapy Polish Academy of Sciences, Wroclaw, Poland.
Anna SzewczykDepartment of Molecular and Cellular Biology, Wroclaw Medical University, Wroclaw, Poland.
Jolanta SaczkoDepartment of Molecular and Cellular Biology, Wroclaw Medical University, Wroclaw, Poland.
Julita KulbackaDepartment of Molecular and Cellular Biology, Wroclaw Medical University, Wroclaw, Poland.
Agnieszka ChwiłkowskaDepartment of Molecular and Cellular Biology, Wroclaw Medical University, Wroclaw, Poland agnieszka.chwilkowska@umed.wroc.pl.
Wroclaw Medical University · PLPolish Academy of Sciences · PLUniversity of Wrocław · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThere is no satisfactory treatment of glioblastoma multiforme, a highly invasive brain tumor. The aim of this study was to analyze the cytotoxic effects of curcumin (CUR) alone and as a photosensitizer on glioblastoma cells. MATERIALS AND

methodsThe SNB-19 cells where incubated for 2 and 24 h with 5-200 mM of CUR. The cells were radiated with blue light (6 J/cm

resultsPhotosensitization of CUR decreased the EC

conclusionCUR is a promising medicament that can be used as a photosensitizer in photodynamic therapy for glioma treatment.

Indexed as

Antineoplastic AgentsApoptosisBrain NeoplasmsCell Line, TumorCurcuminGlioblastomaGliomaHumansMaleMiddle AgedMitochondriaPhotochemotherapyPhotosensitizing AgentsAntineoplastic AgentsCurcuminPhotosensitizing Agentscurcuminexperimental oncologyglioblastomaPhotodynamic reaction

Identifiers

PMID31662513
PMCPMC6899084
OpenAlexW2985185790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.