Evidence map›Paper›PMID 31662496›Full record

SynthesisIn vivo (Athens, Greece)

Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gallbladder: A Systematic Review of Outcomes Following Surgical Management.

Nikolaos Machairas, Anna Paspala, Maximos Frountzas, Diamantis I Tsilimigras, Dimitrios Moris, Vasileia Ntomi, Dimitrios Tsapralis, Dimitrios Schizas

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nikolaos Machairas *3rd Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece nmachair@gmail.com.
Anna Paspala *3rd Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
Maximos FrountzasLaboratory of Experimental Surgery and Surgical Research "N. S. Christeas", National and Kapodistrian University of Athens, Athens, Greece.
Diamantis I TsilimigrasDepartment of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH, U.S.A.
Dimitrios MorisDepartment of Surgery, Duke University Medical Center, Durham, NC, U.S.A.
Vasileia Ntomi3rd Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
Dimitrios TsapralisDepartment of Surgery, General Hospital of Ierapetra, Ierapetra, Greece.
Dimitrios Schizas1st Department of Surgery, National and Kapodistrian University of Athens, Laikon Hospital, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimMixed adenoneuroendocrine carcinomas (MANEC) are uncommon tumors exhibiting both adenocarcinomatous and neuroendocrine differentiation. They most commonly arise in the colon, appendix, rectum or stomach, however, a limited number of MANECs have been reported to originate in the gallbladder (gMANEC). The aim of our systematic review was to accumulate the existing data on gMANEC with special attention to the clinicopathological characteristics, surgical approach, recurrence and survival rates of patients diagnosed with this rare malignancy. MATERIALS AND

methodsA comprehensive search of the literature was undertaken.

resultsA total of 15 studies (14 case reports and 1 case series), which comprised 19 patients who successfully underwent surgical treatment for gMANEC were included in our systematic review. During a median follow-up of 8 months (range=2-48 months) the overall survival was 87% and the recurrence rate was 21%.

conclusionAchievement of complete surgical resection is the mainstay of the therapeutic management. Additionally, the stage of the disease and the histopathological mapping of these tumors affect decision-making for adjuvant chemotherapy and seem to define the prognostic course of each patient.

Indexed as

AdenocarcinomaAnimalsGallbladder NeoplasmsHumansNeoplasm Recurrence, LocalPrognosisadenoneuroendocrinecarcinomaGallbladderMANECmixedreview

Identifiers

PMID31662496
PMCPMC6899129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.