ArticlemBio2019
Crystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target.
Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Antiviral Potential of Brown Algal Metabolites Against A179L Anti-apoptotic Protein: A Computational Strategy for African Swine Fever Treatment.Current topics in medicinal chemistry · 2026Article
- Insights and progress on epidemic characteristics, pathogenesis, and preventive measures of African swine fever virus: A review.Virulence · 2025Review
- Is dUTPase Enzymatic Activity Truly Essential for Viability?International journal of molecular sciences · 2025Review
- Single-Cell Atlas of Spleen Remodeling Reveals Macrophage Subset-Driven ASFV Pathogenesis.Biology · 2025Article
- Marine fungal metabolites as antiviral agents: Computer-aided drug screening for selective inhibition of African swine fever virus dUTPase.BioImpacts : BI · 2025Article
- Structures of African swine fever virus topoisomerase complex and their implications.Nature communications · 2024Article
- Article
- Recent progress on gene-deleted live-attenuated African swine fever virus vaccines.NPJ vaccines · 2024Review
- Identification of two novel linear epitopes on the E165R protein of African swine fever virus recognized by monoclonal antibodies.Frontiers in veterinary science · 2024Article
- Article
- Complete Structural Predictions of the Proteome of African Swine Fever Virus Strain Georgia 2007.Microbiology resource announcements · 2022Article
- Deletion of the ASFV dUTPase GeneViruses · 2022Article
- FoxJ1 inhibits African swine fever virus replication and viral S273R protein decreases the expression of FoxJ1 to impair its antiviral effect.Virologica Sinica · 2022Article
- Structural Insight into Molecular Inhibitory Mechanism of InsPJournal of virology · 2022Article
- A particle size threshold governs diffusion and segregation of PAR-3 during cell polarization.Cell reports · 2022Article
- African Swine Fever Virus Regulates Host Energy and Amino Acid Metabolism To Promote Viral Replication.Journal of virology · 2022Article
- Deletion of theJournal of virology · 2022Article
- The gut virome in two indigenous populations from Malaysia.Scientific reports · 2022Article
- Viral dUTPases: Modulators of Innate Immunity.Biomolecules · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
E165R, a highly specific dUTP nucleotidohydrolase (dUTPase) encoded by the African swine fever virus (ASFV) genome, is required for productive replication of ASFV in swine macrophages. Here, we solved the high-resolution crystal structures of E165R in its apo state and in complex with its product dUMP. Structural analysis explicitly defined the architecture of the active site of the enzyme as well as the interaction between the active site and the dUMP ligand. By comparing the ASFV E165R structure with dUTPase structures from other species, we found that the active site of E165R is highly similar to those of dUTPases from
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