Evidence map›Paper›PMID 31662454›Full record

ArticlemBio2019

Type VII Secretion Substrates of Pathogenic Mycobacteria Are Processed by a Surface Protease.

Maroeska J Burggraaf, Alexander Speer, Aniek S Meijers, Roy Ummels, Astrid M van der Sar, Konstantin V Korotkov, Wilbert Bitter, Coenraad Kuijl

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Vitamin BMicrobiology spectrum · 2024
    Article
  7. Dysregulation ofBiomolecules · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Heterologous Expression ofAntimicrobial agents and chemotherapy · 2021
    Article
  14. Review
  15. PPE38-Secretion-Dependent Proteins ofFrontiers in immunology · 2021
    Article
  16. PE_PGRS proteins ofVirulence · 2020
    Review
  17. Article
  18. Article
  19. Identification of gene fusion events inNAR genomics and bioinformatics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Maroeska J BurggraafAmsterdam UMC, Vrije Universiteit Amsterdam, Medical Microbiology and Infection Control, Cancer Center Amsterdam, Amsterdam, Netherlands.
Alexander SpeerAmsterdam UMC, Vrije Universiteit Amsterdam, Medical Microbiology and Infection Control, Amsterdam Institute of Infection & Immunity, Amsterdam, Netherlands.
Aniek S MeijersAmsterdam UMC, Vrije Universiteit Amsterdam, Medical Microbiology and Infection Control, Amsterdam Institute of Infection & Immunity, Amsterdam, Netherlands.
Roy UmmelsAmsterdam UMC, Vrije Universiteit Amsterdam, Medical Microbiology and Infection Control, Amsterdam Institute of Infection & Immunity, Amsterdam, Netherlands.
Astrid M van der SarAmsterdam UMC, Vrije Universiteit Amsterdam, Medical Microbiology and Infection Control, Amsterdam Institute of Infection & Immunity, Amsterdam, Netherlands.
Konstantin V KorotkovMolecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.ORCID 0000-0002-2182-6843
Wilbert BitterAmsterdam UMC, Vrije Universiteit Amsterdam, Medical Microbiology and Infection Control, Amsterdam Institute of Infection & Immunity, Amsterdam, Netherlands.
Coenraad KuijlAmsterdam UMC, Vrije Universiteit Amsterdam, Medical Microbiology and Infection Control, Amsterdam Institute of Infection & Immunity, Amsterdam, Netherlands c.kuijl@vumc.nl.ORCID 0000-0003-4378-1428
Amsterdam University Medical Centers · NLUniversity of Kentucky · US

Funding

Structure and mechanism of the ESX secretion system from pathogenic mycobacteriaR01AI119022 · NIAID · UNIVERSITY OF KENTUCKY · PI KOROTKOV, KONSTANTIN V · 2015 to 2019
$1.7M
NIAID NIH HHS R01 AI119022
6 · The paper itself

Abstract

Tuberculosis, one of the world's most severe infectious diseases, is caused by

Indexed as

AnimalsBacterial ProteinsCarboxylic Ester HydrolasesCell WallLarvaMycobacterium marinumMycobacterium tuberculosisPeptide HydrolasesType VII Secretion SystemsVirulenceVirulence FactorsZebrafishBacterial ProteinsCarboxylic Ester HydrolasesLipY protein, Mycobacterium tuberculosisPeptide HydrolasesType VII Secretion SystemsVirulence Factorsaspartic proteaseMycobacteriumPE_PGRSPE proteinstype VII secretion

Identifiers

PMID31662454
PMCPMC6819658
OpenAlexW2982450508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.