Evidence map›Paper›PMID 31662453›Full record

ArticlemBio2019

Transient Silencing of Antibiotic Resistance by Mutation Represents a Significant Potential Source of Unanticipated Therapeutic Failure.

Louise Kime, Christopher P Randall, Frank I Banda, Francesc Coll, John Wright, Joseph Richardson, Joanna Empel, Julian Parkhill, Alex J O'Neill

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 67 citations in OpenAlex.

  1. Resistome Profiling of a Large Collection ofInternational journal of molecular sciences · 2026
    Article
  2. Review
  3. Frontiers in veterinary science · 2026
    Article
  4. Article
  5. Nature of bacitracin resistance inAntimicrobial agents and chemotherapy · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Antimicrobial and Phylogenomic Characterization ofAntibiotics (Basel, Switzerland) · 2024
    Article
  14. Article
  15. Comparison of genotypic and phenotypic antimicrobial resistance profiles ofJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Louise KimeSchool of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.ORCID 0000-0002-1743-1136
Christopher P RandallSchool of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.ORCID 0000-0002-9565-8387
Frank I BandaSchool of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Francesc CollInfection Biology Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
John WrightSchool of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Joseph RichardsonSchool of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Joanna EmpelDepartment of Epidemiology and Clinical Microbiology, National Medicines Institute, Warsaw, Poland.
Julian ParkhillDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-7069-5958
Alex J O'NeillSchool of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom a.j.oneill@leeds.ac.uk.ORCID 0000-0003-3222-5493
University of Leeds · GBLondon School of Hygiene & Tropical Medicine · GBNarodowy Instytut Leków · PLUniversity of Cambridge · GB

Funding

Medical Research Council MR/M017710/1Wellcome Trust
6 · The paper itself

Abstract

Sporadic literature reports describe isolates of pathogenic bacteria that harbor an antibiotic resistance determinant but remain susceptible to the corresponding antibiotic as a consequence of a genetic defect. Such strains represent a source from which antibiotic resistance may reemerge to cause treatment failure in patients. Here, we report a systematic investigation into the prevalence and nature of this phenomenon, which we term

Indexed as

Gene SilencingMutationAnti-Bacterial AgentsDrug Resistance, BacterialGenotypeHumansMicrobial Sensitivity TestsPhenotypeStaphylococcal InfectionsStaphylococcus aureusWhole Genome SequencingAnti-Bacterial AgentsSARMsilenced antibiotic resistanceStaphylococcus

Identifiers

PMID31662453
PMCPMC6819657
OpenAlexW2982638943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.