Evidence map›Paper›PMID 31662452›Full record

ReviewmBio2019

Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections

Oren Gordon, Camilo A Ruiz-Bedoya, Alvaro A Ordonez, Elizabeth W Tucker, Sanjay K Jain

Open access · goldAbstract readReview
In one paragraph

Review in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. PET/CT imaging of CSF1R in a mouse model of tuberculosis.European journal of nuclear medicine and molecular imaging · 2022
    Article
  8. Imaging joint infections using D-methyl-European journal of nuclear medicine and molecular imaging · 2022
    Article
  9. Review
  10. PET imaging of TSPO expression in immune cells can assess organ-level pathophysiology in high-consequence viral infections.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Article
  12. In vivo optical molecular imaging of inflammation and immunity.Journal of molecular medicine (Berlin, Germany) · 2021
    Review
  13. Review
  14. Article
  15. Review
  16. European journal of nuclear medicine and molecular imaging · 2021
    Article
  17. Article
  18. Evaluation of Peptide-Based Probes towardACS infectious diseases · 2020
    Article
  19. Rabbit model ofDisease models & mechanisms · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Oren Gordon *Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Camilo A Ruiz-Bedoya *Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Alvaro A OrdonezDivision of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Elizabeth W TuckerCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0971-3635
Sanjay K JainDivision of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA sjain5@jhmi.edu.ORCID 0000-0001-9620-7070
Johns Hopkins University · US

Funding

Research Training in Pediatric Infectious DiseasesT32AI052071 · NIAID · JOHNS HOPKINS UNIVERSITY · PI AARON M MILSTONE · 2002 to 2026
$5.2M
Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial InfectionR01EB020539 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2014 to 2018
$3.6M
Development of 11C-PABA as a bacteria-specific imaging agent for spinal infectionsR01EB025985 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAIN, SANJAY, WILSON, DAVID M · 2018 to 2021
$2.7M
Molecular Imaging for Pulmonary Infections and InflammationR01HL131829 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2016 to 2018
$2.2M
Novel Imaging and host-directed therapy in pediatric CNS TBK08AI139371 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TUCKER, ELIZABETH WINANS · 2019 to 2023
$994k
Preclinical modeling to study Tuberculous MeningitisR56AI145435 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2019 to 2019
$839k
NHLBI NIH HHS R01 HL131829NIAID NIH HHS K08 AI139371NIAID NIH HHS R56 AI145435NIAID NIH HHS T32 AI052071NIBIB NIH HHS R01 EB020539NIBIB NIH HHS R01 EB025985
6 · The paper itself

Abstract

Molecular imaging is an emerging technology that enables the noninvasive visualization, characterization, and quantification of molecular events within living subjects. Positron emission tomography (PET) is a clinically available molecular imaging tool with significant potential to study pathogenesis of infections in humans. PET enables dynamic assessment of infectious processes within the same subject with high temporal and spatial resolution and obviates the need for invasive tissue sampling, which is difficult in patients and generally limited to a single time point, even in animal models. This review presents current state-of-the-art concepts on the application of molecular imaging for infectious diseases and details how PET imaging can facilitate novel insights into infectious processes, ongoing development of pathogen-specific imaging, and simultaneous

Indexed as

AnimalsAnti-Infective AgentsDisease Models, AnimalHumansInfectionsMolecular ImagingPositron-Emission TomographyAnti-Infective Agentsheterogeneityinfectious diseasemolecular imagingpathogenesispositron emission tomography

Identifiers

PMID31662452
PMCPMC6819656
OpenAlexW2982396146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.