ArticleBMJ open2019
Female reproductive history in relation to chronic obstructive pulmonary disease and lung function in UK biobank: a prospective population-based cohort study.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Shared genetic architecture and cellular convergence between female reproductive disorders and pulmonary function: a genome-wide cross-trait analysis.Functional & integrative genomics · 2026Article
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- Sex and Gender in Chronic Obstructive Pulmonary Disease: Does It Matter?Journal of personalized medicine · 2026Review
- Review
- Adverse pregnancy outcomes and lung function later in life: The CARDIA lung study.Respiratory medicine · 2025Article
- Postoperative stroke in CABG: a ten-year study of stroke incidence and contributing risk factors in Jordan.Journal of medicine and life · 2025Observational
- Gender, tobacco and chronic obstructive pulmonary disease: analysis of the 2020 National Health Interview Survey.BMJ open respiratory research · 2025Article
- Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body.Aging and disease · 2025Review
- The impact of hormones on lung development and function: an overlooked aspect to consider from early childhood.Frontiers in endocrinology · 2024Review
- Early life exposures contributing to accelerated lung function decline in adulthood - a follow-up study of 11,000 adults from the general population.EClinicalMedicine · 2023Article
- Article
- Associations of reproductive risk score and joint exposure to ambient air pollutants with chronic obstructive pulmonary disease: a cohort study in UK Biobank.Environmental health and preventive medicine · 2023Article
- The Mediating Role of Body Mass Index in the Association Between Age at First Childbirth and Lung Function Among Chinese Postmenopausal Women.Clinical epidemiology · 2023Article
- Effect of smoking on the development of chronic obstructive pulmonary disease in young individuals: a nationwide cohort study.Frontiers in medicine · 2023Article
- Early natural menopause is associated with poor lung health and increased mortality among female smokers.American journal of obstetrics and gynecology · 2022Article
- A population-based cohort study on the risk of obstructive lung disease after bilateral oophorectomy.NPJ primary care respiratory medicine · 2022Article
- Why a large percentage of Tunisian women aged 40 years and more has a reduced forced vital capacity? The implication of parity.BMC pulmonary medicine · 2022Article
- Article
- The relationships between women's reproductive factors: a Mendelian randomisation analysis.BMC medicine · 2022Article
- Female Reproductive Factors and the Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study.Biomedicines · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
objectivesSex differences in respiratory physiology and predilection for developing chronic obstructive pulmonary disease (COPD) have been documented, suggesting that female sex hormones may influence pathogenesis. We investigated whether aspects of female reproductive health might play a role in risk of COPD among women.
designPopulation-based prospective cohort study.
settingUK Biobank recruited across 22 centres in the UK between 2006 to 2010. PRIMARY AND SECONDARY OUTCOMES MEASURES: We examined a range of female reproductive health indicators in relation to risk of COPD-related hospitalisation/death (n=271 271) using Cox proportional hazards regression; and lung function (n=273 441) using linear regression.
resultsParity >3 was associated with greater risk of COPD-related hospitalisation/death (adjusted HR 1.45; 95% CI: 1.16 to 1.82) and lower forced expiratory volume at 1 second/forced vital capacity ratio (FEV
conclusionsMultiple female reproductive health indicators across the life course are associated with COPD-related hospitalisation/death and lung function. Further studies are necessary to understand the opposing associations of PCOS/ovarian cysts, HRT and hysterectomy with COPD and objective measures of airway obstruction.
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