ArticleBMJ open2019
Effect of diabetes mellitus on risk of latent TB infection in a high TB incidence area: a community-based study in Taiwan.
Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Diabetes mellitus and latent tuberculosis infection: an updated meta-analysis and systematic review.BMC infectious diseases · 2023Pooled it
- The Association Between Diabetes Mellitus and the Risk of Latent Tuberculosis Infection: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- The association of glycemic level and prevalence of tuberculosis: a meta-analysis.BMC endocrine disorders · 2021Pooled it
- Pooled it
- LTBI Prevalence and Risk Factors in Field Practice Areas of a Tertiary Care Hospital, Jodhpur, Rajasthan.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026Article
- Interferon-gamma release assay screening before solid organ transplantation in a low-incidence country: a prospective single-center cohort study.Scientific reports · 2026Article
- A QuantiFERONInfection and drug resistance · 2026Article
- A cost-effectiveness evaluation of methods for screening for TB infection in patients with diabetes mellitus.IJTLD open · 2025Article
- Poor glycemic control among people with diabetes mellitus is associated with tuberculosis infection: a cross-sectional study in Nepal.BMC infectious diseases · 2025Article
- Long-term impact of national tuberculosis program interventions on incidence and disparities by age and geography.BMC infectious diseases · 2025Article
- Role of interferon-gamma release assay for screening and monitoring of latent tuberculosis infection in kidney transplant recipients.BMC infectious diseases · 2024Article
- Latent tuberculosis infection and diagnostic performance of the tuberculin skin test among type 2 diabetics in Sana'a city, Yemen.BMC infectious diseases · 2024Article
- Protective Effect of BCG and Neutrophil-to-Lymphocyte Ratio on Latent Tuberculosis in End Stage Renal Disease.Infectious diseases and therapy · 2023Article
- Review
- Prevalence of proximate risk factors of active tuberculosis in latent tuberculosis infection: A cross-sectional study from South India.Frontiers in public health · 2022Article
- Prevalence of latent tuberculosis infection among participants of the national LTBI screening program in South Korea - A problem of low coverage rate with current LTBI strategy.Frontiers in public health · 2022Article
- Increased susceptibility to pneumonia due to tumour necrosis factor inhibition and prospective immune system rescueFrontiers in cellular and infection microbiology · 2022Review
- Implementation of the WHO's collaborative framework for the management of tuberculosis and diabetes: a scoping review.BMJ open · 2021Article
- Diabetes and tuberculosis: a syndemic complicated by COVID-19.Medicina clinica · 2021Review
- Diabetes and tuberculosis: A syndemic complicated by COVID-19.Medicina clinica (English ed.) · 2021Review
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between diabetes and latent tuberculosis infections (LTBI) in high TB incidence areas.
designCommunity-based comparison study.
settingOutpatient diabetes clinics at 4 hospitals and 13 health centres in urban and rural townships. A community-based screening programme was used to recruit non-diabetic participants.
participantsA total of 2948 patients with diabetes aged older than 40 years were recruited, and 453 non-diabetic participants from the community were enrolled. PRIMARY AND SECONDARY OUTCOME MEASURES: The interferon-gamma release assay (IGRA) and the tuberculin skin test were used to detect LTBI. The IGRA result was used as a surrogate of LTBI in logistic regression analysis.
resultsDiabetes was significantly associated with LTBI (adjusted OR (aOR)=1.59; 95% CI 1.11 to 2.28) and age correlated positively with LTBI. Many subjects with diabetes also had additional risk factors (current smokers (aOR=1.28; 95% CI 0.95 to 1.71), comorbid chronic kidney disease (aOR=1.26; 95% CI 1.03 to 1.55) and history of TB (aOR=2.08; 95% CI 1.19 to 3.63)). The presence of BCG scar was protective (aOR=0.66; 95% CI 0.51 to 0.85). Duration of diabetes and poor glycaemic control were unrelated to the risk of LTBI.
conclusionThere was a moderately increased risk of LTBI in patients with diabetes from this high TB incidence area. This finding suggests LTBI screening for the diabetics be combined with other risk factors and comorbidities of TB to better identify high-risk groups and improve the efficacy of targeted screening for LTBI.
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