ArticleJournal of the Royal Society, Interface2019
Force chains in cell-cell mechanical communication.
Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Compressive instabilities enable cell-induced extreme densification patterns in the fibrous extracellular matrix: Discrete model predictions.PLoS computational biology · 2024Article
- Biophysical perspectives to understanding cancer-associated fibroblasts.APL bioengineering · 2024Review
- Unexpected softening of a fibrous matrix by contracting inclusions.Acta biomaterialia · 2024Article
- Clots reveal anomalous elastic behavior of fiber networks.Science advances · 2024Article
- Inference of long-range cell-cell force transmission from ECM remodeling fluctuations.Communications biology · 2023Article
- Hybrid cellular Potts and bead-spring modeling of cells in fibrous extracellular matrix.Biophysical journal · 2023Article
- A cell-based framework for modeling cardiac mechanics.Biomechanics and modeling in mechanobiology · 2023Article
- Mechanical communication-associated cell directional migration and branching connections mediated by calcium channels, integrin β1, and N-cadherin.Frontiers in cell and developmental biology · 2022Article
- A computational framework for modeling cell-matrix interactions in soft biological tissues.Biomechanics and modeling in mechanobiology · 2021Article
- Cells exploit a phase transition to mechanically remodel the fibrous extracellular matrix.Journal of the Royal Society, Interface · 2021Article
- Long-range mechanical signaling in biological systems.Soft matter · 2021Review
- Long-range mechanical coupling of cells in 3D fibrin gels.Molecular biology of the cell · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Force chains (FCs) are a key determinant of the micromechanical properties and behaviour of heterogeneous materials, such as granular systems. However, less is known about FCs in fibrous materials, such as the networks composing the extracellular matrix (ECM) of biological systems. Using a finite-element computational model, we simulated the contraction of a single cell and two nearby cells embedded in two-dimensional fibrous elastic networks and analysed the tensile FCs that developed in the ECM. The role of ECM nonlinear elasticity on FC formation was evaluated by considering linear and nonlinear, i.e. exhibiting 'buckling' and/or 'strain-stiffening', stress-strain curves. The effect of the degree of cell contraction and network coordination value was assessed. We found that nonlinear elasticity of the ECM fibres influenced the structure of the FCs, facilitating the transition towards more distinct chains that were less branched and more radially oriented than the chains formed in linear elastic networks. When two neighbouring cells contract, a larger number of FCs bridged between the cells in nonlinear networks, and these chains had a larger effective rigidity than the chains that did not reach a neighbouring cell. These results suggest that FCs function as a route for mechanical communication between distant cells and highlight the contribution of ECM fibre nonlinear elasticity to the formation of FCs.
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