Evidence map›Paper›PMID 31661959›Full record

ArticleBioconjugate chemistry2019

Dextran-Benzoporphyrin Derivative (BPD) Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Micelles for T

Lesan Yan, Lijun Luo, Ahmad Amirshaghaghi, Joann Miller, Cathy Meng, Tianyan You, Theresa M Busch, Andrew Tsourkas, Zhiliang Cheng

Abstract read
In one paragraph

Article in Bioconjugate chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Imaging Constructs: The Rise of Iron Oxide Nanoparticles.Molecules (Basel, Switzerland) · 2021
    Review
  9. Article
  10. Understanding the mechanisms of silica nanoparticles for nanomedicine.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021
    Review
  11. Magnetic particle targeting for diagnosis and therapy of lung cancers.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lesan YanDepartment of Bioengineering, School of Engineering and Applied Sciences , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.ORCID 0000-0003-3616-9628
Lijun LuoDepartment of Bioengineering, School of Engineering and Applied Sciences , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Ahmad AmirshaghaghiDepartment of Bioengineering, School of Engineering and Applied Sciences , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Joann MillerDepartment of Radiation Oncology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Cathy MengDepartment of Bioengineering, School of Engineering , University of California Berkeley , Berkeley , California 94720 , United States.
Tianyan YouSchool of Agricultural Equipment Engineering , Jiangsu University , Zhenjiang , Jiangsu 212013 , China.ORCID 0000-0003-1579-7078
Theresa M BuschDepartment of Radiation Oncology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Andrew TsourkasDepartment of Bioengineering, School of Engineering and Applied Sciences , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.ORCID 0000-0001-7758-1753
Zhiliang ChengDepartment of Bioengineering, School of Engineering and Applied Sciences , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.ORCID 0000-0003-3351-6874

Funding

TUMOR HYPOXIA, PHOTOSENSITIZER, VASCULARITY AND PDTP01CA087971 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BUSCH, THERESA M, CENGEL, KEITH A · 2001 to 2019
$24.8M
Effects of Photodynamic Therapy on Tumor Oxygenation and Blood FlowR01CA085831 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BUSCH, THERESA M · 2001 to 2018
$4.7M
Radiation and Receptor Targeted RadioTheranostic Nanoparticles for GlioblastomaR01CA181429 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DORSEY, JAY FITZGERALD · 2014 to 2018
$2.4M
Targeted treatment for radiculopathy via engineered PLA2-responsive multifunctional micellesR01NS100892 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI CHENG, ZHILIANG · 2017 to 2021
$1.7M
Tumor-targeted Polymersomes to image and Treat Ovarian CancerR01CA175480 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CHENG, ZHILIANG · 2013 to 2017
$1.6M
NCI NIH HHS P01 CA087971NCI NIH HHS R01 CA085831NCI NIH HHS R01 CA175480NCI NIH HHS R01 CA181429NINDS NIH HHS R01 NS100892
6 · The paper itself

Abstract

Photodynamic therapy (PDT) has attracted extensive attention in recent years as a noninvasive and locally targeted cancer treatment approach. Nanoparticles have been used to improve the solubility and pharmacokinetics of the photosensitizers required for PDT; however, nanoparticles also suffer from many shortcomings including uncontrolled drug release and low tumor accumulation. Herein, we describe a novel biodegradable nanoplatform for the delivery of the clinically used PDT photosensitizer benzoporphyrin derivative monoacid ring A (BPD-MA) to tumors. Specifically, the hydrophobic photosensitizer BPD was covalently conjugated to the amine groups of a dextran-

Indexed as

PhotochemotherapyAnimalsBreast NeoplasmsCell ProliferationContrast MediaDextransDrug LiberationFemaleFerric CompoundsHumansMagnetic Resonance ImagingMagnetite NanoparticlesMiceMice, Inbred BALB CMicellesMice, Nudebenzoporphyrin DContrast MediaDextransFerric Compoundsferric oxideMagnetite NanoparticlesMicellesPhotosensitizing AgentsPolymersPorphyrins

Identifiers

PMID31661959
PMCPMC7241292

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.