Evidence map›Paper›PMID 31661783›Full record

ArticleMetabolites2019

A Lipidomic Analysis of Docosahexaenoic Acid (22:6, ω3) Mediated Attenuation of Western Diet Induced Nonalcoholic Steatohepatitis in Male

Manuel García-Jaramillo, Kelli A Lytle, Melinda H Spooner, Donald B Jump

Open access · goldAbstract read
In one paragraph

Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
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  5. Hepatic oxylipin profiles in mouse models of Wilson disease: New insights into early hepatic manifestations.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2024
    Article
  6. Review
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  9. Myeloid cell MHC I expression drives CD8Frontiers in immunology · 2023
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Manuel García-JaramilloNutrition Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA. Manuel.g.jaramillo@oregonstate.edu.ORCID 0000-0003-2987-2913
Kelli A LytleNutrition Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA. Kelli.Lytle@mayo.edu.
Melinda H SpoonerNutrition Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA. Spoonerm@oregonstate.edu.
Donald B JumpNutrition Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA. Donald.Jump@oregonstate.edu.ORCID 0000-0002-9473-6283
Oregon State University · US

Funding

Omega-3 fatty acids and the control of fatty liver diseaseR01DK112360 · NIDDK · OREGON STATE UNIVERSITY · PI JUMP, DONALD B · 2017 to 2020
$1.3M
PUFA Synthesis and the Control of Hepatic MetabolismR01DK094600 · NIDDK · OREGON STATE UNIVERSITY · PI JUMP, DONALD B · 2012 to 2015
$1.2M
NIDDK NIH HHS DK094600, DK112360NIDDK NIH HHS R01 DK112360
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a major public health problem worldwide. NAFLD ranges in severity from benign steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis, and primary hepatocellular cancer (HCC). Obesity and type 2 diabetes mellitus (T2DM) are strongly associated with NAFLD, and the western diet (WD) is a major contributor to the onset and progression of these chronic diseases. Our aim was to use a lipidomic approach to identify potential lipid mediators of diet-induced NASH. We previously used a preclinical mouse (low density lipoprotein receptor null mouse,

Indexed as

arachidonic aciddocosahexaenoic acidfibrosisinflammationlipidomicsmass spectrometrynonalcoholic fatty liver diseasenonalcoholic steatohepatitis

Identifiers

PMID31661783
PMCPMC6918288
OpenAlexW2981595448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.