Evidence map›Paper›PMID 31661601›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2019

Blood pressure in relation to frailty in older adults: A population-based study.

Daniela Anker, Brigitte Santos-Eggimann, Marcel Zwahlen, Valérie Santschi, Nicolas Rodondi, Christina Wolfson, Arnaud Chiolero

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Frailty and blood pressure in older adults: rethinking risk and treatment strategies.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
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  15. Pre-Frailty Phenotype and Arterial Stiffness in Older Adults Free of Cardiovascular Diseases.International journal of environmental research and public health · 2022
    Article
  16. Cohort Profile: The Lausanne cohort 65+ (Lc65+).International journal of epidemiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Daniela AnkerInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.ORCID 0000-0002-0607-0283
Brigitte Santos-EggimannCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Marcel ZwahlenInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Valérie SantschiLa Source, School of nursing sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Lausanne, Switzerland.ORCID 0000-0002-4452-8857
Nicolas RodondiInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Christina WolfsonDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Quebec, Canada.
Arnaud ChioleroInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
University of Bern · CHCentre universitaire de médecine générale et santé publique, Lausanne · CHHES-SO University of Applied Sciences and Arts Western Switzerland · CHMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In frail older adults, low blood pressure (BP) might be associated with worse health outcomes and hypertension management in this population is highly debated. Using data from a population-based study of older adults, we assessed the association between frailty and BP. We used data collected between 2014 and 2016 from 3157 participants aged between 67 and 80 years in the Lausanne cohort Lc65+. BP was measured three times at one visit, and frailty status was assessed based on Fried's phenotype model. We analyzed the cross-sectional association between BP and frailty by computing mean systolic and diastolic BP stratified by sex, age, and frailty and by fitting regression models. The average age of the participants was 73.3 (standard deviation [SD]: 4.1) years, and 59.1% were women. 34.1% were pre-frail, and 3.3% were frail. Mean BP was 135.1/76.3 mm Hg (SD 18.5/11.0). Age- and sex-adjusted systolic BP was on average lower by 2.8 mm Hg (95% confidence interval [CI]: 1.4-4.2) and 6.7 mm Hg (95% CI: 3.2-10.3) among pre-frail and frail compared to non-frail participants. Similar differences in mean diastolic BP across frailty status were found. Upon adjustment for antihypertensive treatment, the associations between frailty status and BP did not change substantially. Frail individuals had a substantially lower BP compared with non-frail older adults. Because low BP could be detrimental among frail older patients, our findings raise questions about hypertension management in this population and stress the need for additional evidence.

Indexed as

AgedAged, 80 and overAntihypertensive AgentsBlood PressureBlood Pressure DeterminationCase-Control StudiesCross-Sectional StudiesDiastoleFemaleFrail ElderlyHumansHypertensionMaleSwitzerlandSystoleAntihypertensive Agentsepidemiologyfrailtyhypertension in the elderlyobservationalpopulation-based

Identifiers

PMID31661601
PMCPMC8030340
OpenAlexW2982525902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.