ArticleJournal of biophotonics2020
Photoacoustic imaging of the human placental vasculature.
Article in Journal of biophotonics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Photoacoustic and ultrasound Imaging of placental functions in gestational diabetes: From diagnosis to precision interventions.Photoacoustics · 2026Review
- Noninvasive multimodal photoacoustic-ultrasound imaging for dynamic assessment of placental hypoxia and perfusion in preeclampsia.Photoacoustics · 2026Article
- Sound of nurturing: Advanced photoacoustic and ultrasound imaging of placental hemodynamics.Placenta · 2026Article
- From light to sound: Seeing and hearing the placenta in health and disease.Science advances · 2026Review
- Development of a Dual Photoacoustic-Ultrasound Imaging System: Current Status and Future Perspectives.Sensors (Basel, Switzerland) · 2026Review
- Needle hydrophone-based photoacoustic microscopy with experimentally measured impulse response for improved depth of focus.Biomedical optics express · 2025Article
- Nanomedicines for Improved Management of Ectopic Pregnancy: A Narrative Review.Small (Weinheim an der Bergstrasse, Germany) · 2024Review
- A flexible generative algorithm for growing in silico placentas.PLoS computational biology · 2024Article
- Compensating unknown speed of sound in learned fast 3D limited-view photoacoustic tomography.Photoacoustics · 2024Article
- Functional Photoacoustic Imaging for Placental Monitoring: A Mini Review.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Review
- A review of feto-placental vasculature flow modelling.Placenta · 2023Review
- Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast.Photoacoustics · 2023Review
- Integrated Ultrasound and Photoacoustic-Guided Laser Ablation Theranostic Endoscopic System.IEEE transactions on bio-medical engineering · 2023Article
- Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: "Always-On" and "Turn-On" Probes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Oxygen saturation and blood volume analysis by photoacoustic imaging to identify pre and post-PDT vascular changes.Saudi journal of biological sciences · 2022Article
- Monitoring peripheral hemodynamic response to changes in blood pressure via photoacoustic imaging.Photoacoustics · 2022Article
- Full-view in vivo skin and blood vessels profile segmentation in photoacoustic imaging based on deep learning.Photoacoustics · 2022Article
- Clinical photoacoustic/ultrasound dual-modal imaging: Current status and future trends.Frontiers in physiology · 2022Review
- Photoacoustic assessment of the fetal brain and placenta as a method of non-invasive antepartum and intrapartum monitoring.Experimental neurology · 2022Review
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
Minimally invasive fetal interventions require accurate imaging from inside the uterine cavity. Twin-to-twin transfusion syndrome (TTTS), a condition considered in this study, occurs from abnormal vascular anastomoses in the placenta that allow blood to flow unevenly between the fetuses. Currently, TTTS is treated fetoscopically by identifying the anastomosing vessels, and then performing laser photocoagulation. However, white light fetoscopy provides limited visibility of placental vasculature, which can lead to missed anastomoses or incomplete photocoagulation. Photoacoustic (PA) imaging is an alternative imaging method that provides contrast for hemoglobin, and in this study, two PA systems were used to visualize chorionic (fetal) superficial and subsurface vasculature in human placentas. The first system comprised an optical parametric oscillator for PA excitation and a 2D Fabry-Pérot cavity ultrasound sensor; the second, light emitting diode arrays and a 1D clinical linear-array ultrasound imaging probe. Volumetric photoacoustic images were acquired from ex vivo normal term and TTTS-treated placentas. It was shown that superficial and subsurface branching blood vessels could be visualized to depths of approximately 7 mm, and that ablated tissue yielded negative image contrast. This study demonstrated the strong potential of PA imaging to guide minimally invasive fetal therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.