ArticleJCI insight2019
Proteasome inhibition preserves longitudinal growth of denervated muscle and prevents neonatal neuromuscular contractures.
Article in JCI insight, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Brachial plexus birth injury in children and adolescents: A current concepts review.Journal of children's orthopaedics · 2026Review
- A Multidisciplinary Approach to Brachial Plexus Birth Injury: An Overview and Institutional Experience.Seminars in plastic surgery · 2025Review
- Sexual dimorphisms in skeletal muscle: current concepts and research horizons.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Review
- The role of sympathetic innervation in neonatal muscle growth and neuromuscular contractures.The FEBS journal · 2023Article
- Management of Brachial Plexus Birth Injury: The SickKids Experience.Seminars in plastic surgery · 2023Review
- Article
- Insights into muscle stem cell dynamics during postnatal development.The FEBS journal · 2022Review
- Brachial plexus birth injury and cerebral palsy lead to a common contracture phenotype characterized by reduced functional muscle length and strength.Frontiers in rehabilitation sciences · 2022Article
- Skeletal muscle fibers count on nuclear numbers for growth.Seminars in cell & developmental biology · 2021Review
- NRG/ErbB signaling regulates neonatal muscle growth but not neuromuscular contractures in neonatal brachial plexus injury.FEBS letters · 2021Article
- Timing of proteasome inhibition as a pharmacologic strategy for prevention of muscle contractures in neonatal brachial plexus injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains.Nature communications · 2020Article
- Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis.eLife · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Muscle contractures are a prominent and disabling feature of many neuromuscular disorders, including the 2 most common forms of childhood neurologic dysfunction: neonatal brachial plexus injury (NBPI) and cerebral palsy. There are currently no treatment strategies to directly alter the contracture pathology, as the pathogenesis of these contractures is unknown. We previously showed in a mouse model of NBPI that contractures result from impaired longitudinal muscle growth. Current presumed explanations for growth impairment in contractures focus on the dysregulation of muscle stem cells, which differentiate and fuse to existing myofibers during growth, as this process has classically been thought to control muscle growth during the neonatal period. Here, we demonstrate in a mouse model of NBPI that denervation does not prevent myonuclear accretion and that reduction in myonuclear number has no effect on functional muscle length or contracture development, providing definitive evidence that altered myonuclear accretion is not a driver of neuromuscular contractures. In contrast, we observed elevated levels of protein degradation in NBPI muscle, and we demonstrate that contractures can be pharmacologically prevented with the proteasome inhibitor bortezomib. These studies provide what we believe is the first strategy to prevent neuromuscular contractures by correcting the underlying deficit in longitudinal muscle growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.