ArticleAmerican journal of respiratory and critical care medicine2020
The Effects of Rare
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
35 citing papers in PubMed, 57 citations in OpenAlex.
- Z variant heterozygosity in alpha-1 antitrypsin deficiency: disease risk and treatment implications.Orphanet journal of rare diseases · 2026Article
- Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction.Nature genetics · 2026Article
- Reply to AbushanabAnnals of the American Thoracic Society · 2025Article
- Matrix metalloproteinases and disease severity among PI*MZ and PI*ZZ individuals in the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) cohort.BMJ open respiratory research · 2025Article
- Increased exacerbations and hospitalizations among PI*MZ compared to PI*MM individuals: an electronic health record analysis.Respiratory research · 2025Article
- αThe journal of allergy and clinical immunology. In practice · 2025Article
- Longitudinal Outcomes in Pi*MZ Alpha-1 Antitrypsin-Deficient Individuals with Tobacco Smoking History from the SPIROMICS Cohort.Annals of the American Thoracic Society · 2025Article
- SERPINA1 is a new frontier in cancer immunotherapy and drug targeting by pan-cancer analysis.Discover oncology · 2025Article
- Clinical Characteristics of Chronic Obstructive Pulmonary Disease according to Smoking Status.Tuberculosis and respiratory diseases · 2025Article
- Multi-trait and multi-ancestry genetic analysis of comorbid lung diseases and traits improves genetic discovery and polygenic risk prediction.medRxiv : the preprint server for health sciences · 2024Article
- Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.The Journal of allergy and clinical immunology · 2024Article
- Alpha-1 Antitrypsin Phenotyping: An Unmet Educational Need of Healthcare Providers.Journal of clinical medicine research · 2024Article
- Alpha-1 Antitrypsin PI M Heterozygotes with Rare Variants: Do They Need a Clinical and Functional Follow-Up?Journal of clinical medicine · 2024Article
- Alpha-1 Antitrypsin Gene Variants in Patients without Severe Deficiency Diagnosed with Pulmonary Emphysema on Chest CT.International journal of chronic obstructive pulmonary disease · 2024Article
- Undiagnosed Alpha-1 Antitrypsin Deficiency and the Perpetuation of Lung Health Inequity.American journal of respiratory and critical care medicine · 2024Article
- Article
- Testing Alpha-1 Antitrypsin Deficiency in Black Populations.Advances in respiratory medicine · 2023Review
- Impact of Bronchiectasis on COPD Severity and Alpha-1 Antitrypsin Deficiency as a Risk Factor in Individuals with a Heavy Smoking History.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2023Article
- Bulb ofJournal of microbiology and biotechnology · 2023Article
- Pulmonary Function and Respiratory Diseases in Different Genotypes of Alpha-1 Antitrypsin Deficiency.Turkish thoracic journal · 2022Article
Corrections and comments
- Commented on by
Authors and funding
25 authors at 11 institutions in 2 countries.
Victor E OrtegaCenter for Precision Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Xingnan LiDepartment of Medicine, University of Arizona, Tucson, Arizona.
Wanda K O'NealUniversity of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
Lela LackeyDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Elizabeth AmplefordCenter for Precision Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Gregory A HawkinsCenter for Precision Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Philip J GrayeskiUniversity of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
Alain LaederachDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Igor BarjaktarevicDepartment of Medicine, David Geffen School of Medicine, Los Angeles, California.
R Graham BarrColumbia University Medical Center, New York City, New York.
Christopher CooperDepartment of Medicine, David Geffen School of Medicine, Los Angeles, California.
David CouperUniversity of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Richard E KannerDivision of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah.
Eric C KleerupDepartment of Medicine, David Geffen School of Medicine, Los Angeles, California.
Fernando J MartinezDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Weill Cornell Medical College of Cornell University, New York City, New York.
Robert PaineDivision of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah.
Stephen P PetersCenter for Precision Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Cheryl PirozziDivision of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah.
Stephen I RennardDivision of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Nebraska, Omaha, Nebraska.
Prescott G WoodruffDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California; and.
Eric A HoffmanDepartment of Radiology.
Deborah A MeyersDepartment of Medicine, University of Arizona, Tucson, Arizona.
Eugene R BleeckerDepartment of Medicine, University of Arizona, Tucson, Arizona.
NHLBI Subpopulations and Intermediate Outcomes Measures in COPD Study (SPIROMICS)
University of North Carolina at Chapel Hill · USWake Forest University · USUniversity of Arizona · USUniversity of California, Los Angeles · USUniversity of Utah · USAstraZeneca (United Kingdom) · GBColumbia University Irving Medical Center · USCornell University · USMichigan Medicine · USUniversity of California, San Francisco · USUniversity of Iowa · US
Funding
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MSPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2MNon-coding RNA structure change in Chronic Obstructive Pulmonary DiseaseR01HL111527 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Alain T Laederach, Kevin M Weeks · 2012 to 2026
$6.6MEffects of Rare Variants and Ancestry on Beta Agonist Response in Asthma and COPDR01HL142992 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ORTEGA, VICTOR E. · 2019 to 2023
$3.7MStructural and functional consequences of disease SNPs on the transcriptomeR01GM101237 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAEDERACH, ALAIN T · 2012 to 2020
$2.5MUltra-low Dose, High Speed, High Resolution, Multispectral, Multi-Source MDCT ScaS10OD018526 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2015 to 2015
$2.0MMentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2MEffects of Rare Variants and Ancestry on Beta Agonist Response In AsthmaK08HL118128 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ORTEGA, VICTOR E. · 2015 to 2017
$404kNHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS HHSN268201100037CNHLBI NIH HHS K08 HL118128NHLBI NIH HHS K24 HL137013NHLBI NIH HHS R01 HL111527NHLBI NIH HHS R01 HL142992NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIDDK NIH HHS P30 DK054759NIGMS NIH HHS R01 GM101237NIH HHS S10 OD018526
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAgedAged, 80 and overalpha 1-AntitrypsinBlack or African AmericanFemaleForced Expiratory VolumeGenotypeHeterozygoteHispanic or LatinoHumansIsoelectric FocusingLungMaleMaximal Midexpiratory Flow RateMiddle Agedalpha 1-AntitrypsinSERPINA1 protein, humanalpha-1 antitrypsinchronic obstructive pulmonary diseaseemphysemarare variantSERPINA1
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.