ArticleHuman brain mapping2020
White matter tract myelin maturation and its association with general psychopathology in adolescence and early adulthood.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Associations of general and specific psychopathology factors by age 35 with dementia after age 50: a Swedish population-based sibling comparison study.Molecular psychiatry · 2026Article
- Protracted Maturation of Proactive and Reactive Systems Predicts Cognitive Stability and Psychopathology : A longitudinal multi-cohort study.bioRxiv : the preprint server for biology · 2026Article
- Polyphenol intake and depressive symptoms in young adults: evidence from a population-based longitudinal study.The British journal of nutrition · 2025Article
- Brain iron distribution in transdiagnostic mental health burden.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Choline in Adolescent Pregnancy: The Impact on Fetal Brain Development and Long-Term Cognitive Outcomes of Offspring.Medicina (Kaunas, Lithuania) · 2025Review
- Reduced brain structural similarity is associated with maturation, neurobiological features, and clinical status in schizophrenia.Nature communications · 2025Article
- Early adversity alters brain architecture and increases susceptibility to mental health disorders.Nature reviews. Neuroscience · 2025Review
- Intrinsic Functional Connectivity Associated with γ‑Aminobutyric Acid and Glutamate/Glutamine in the Lateral Prefrontal Cortex and Internalizing Psychopathology in Adolescents.Neuroscience bulletin · 2025Article
- White matter microstructure abnormalities in children experiencing neglect without other forms of maltreatment.Scientific reports · 2025Article
- Article
- Leveraging ultra-high field (7T) MRI in psychiatric research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences.Communications medicine · 2024Article
- An open relaxation-diffusion MRI dataset in neurosurgical studies.Scientific data · 2024Article
- Bayesian accounts of perceptual decisions in the nonclinical continuum of psychosis: Greater imprecision in both top-down and bottom-up processes.PLoS computational biology · 2023Article
- AimSeg: A machine-learning-aided tool for axon, inner tongue and myelin segmentation.PLoS computational biology · 2023Article
- Reduced volume of the left cerebellar lobule VIIb and its increased connectivity within the cerebellum predict more general psychopathology one year later via worse cognitive flexibility in children.Developmental cognitive neuroscience · 2023Article
- Person-centred Approaches to Psychopathology in the ABCD Study: Phenotypes and Neurocognitive Correlates.Research on child and adolescent psychopathology · 2023Article
- Novel insights into axon diameter and myelin content in late childhood and adolescence.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Development of morning-eveningness in adolescence: implications for brain development and psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Associations between socioeconomic status and white matter microstructure in children: indirect effects via obesity and cognition.medRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Adolescence is a time period associated with marked brain maturation that coincides with an enhanced risk for onset of psychiatric disorder. White matter tract myelination, a process that continues to unfold throughout adolescence, is reported to be abnormal in several psychiatric disorders. Here, we ask whether psychiatric vulnerability is linked to aberrant developmental myelination trajectories. We assessed a marker of myelin maturation, using magnetisation transfer (MT) imaging, in 10 major white matter tracts. We then investigated its relationship to the expression of a general psychopathology "p-factor" in a longitudinal analysis of 293 healthy participants between the ages of 14 and 24. We observed significant longitudinal MT increase across the full age spectrum in anterior thalamic radiation, hippocampal cingulum, dorsal cingulum and superior longitudinal fasciculus. MT increase in the inferior fronto-occipital fasciculus, inferior longitudinal fasciculus and uncinate fasciculus was pronounced in younger participants but levelled off during the transition into young adulthood. Crucially, longitudinal MT increase in dorsal cingulum and uncinate fasciculus decelerated as a function of mean p-factor scores over the study period. This suggests that an increased expression of psychopathology is closely linked to lower rates of myelin maturation in selective brain tracts over time. Impaired myelin growth in limbic association fibres may serve as a neural marker for emerging mental illness during the course of adolescence and early adulthood.
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