ArticleJournal of cardiovascular electrophysiology2019
Imaging of subendocardial adipose tissue and fiber orientation distributions in the human left atrium using optical coherence tomography.
Article in Journal of cardiovascular electrophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Current Advances in Spatial Pathology of Nasal Polyps: Challenges, Opportunities for Artificial Intelligence, and Future Directions.World journal of otorhinolaryngology - head and neck surgery · 2026Review
- Robust, high-density lesion mapping in the left atrium with near-infrared spectroscopy.Journal of biomedical optics · 2024Article
- Cardiac Adipose Tissue Segmentation via Image-Level Annotations.IEEE journal of biomedical and health informatics · 2023Article
- Cardiac endocardial left atrial substrate and lesion depth mapping using near-infrared spectroscopy.Biomedical optics express · 2022Article
- Quantification of irrigated lesion morphology using near-infrared spectroscopy.Scientific reports · 2021Article
- Anisotropic Mechanical Properties of the Human Uterus Measured by Spherical Indentation.Annals of biomedical engineering · 2021Article
- Imaging of subendocardial adipose tissue and fiber orientation distributions in the human left atrium using optical coherence tomography.Journal of cardiovascular electrophysiology · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundOptical coherence tomography (OCT) has the potential to provide real-time imaging guidance for atrial fibrillation ablation, with promising results for lesion monitoring. OCT can also offer high-resolution imaging of tissue composition, but there is insufficient cardiac OCT data to inform the use of OCT to reveal important tissue architecture of the human left atrium. Thus, the objective of this study was to define OCT imaging data throughout the human left atrium, focusing on the distribution of adipose tissue and fiber orientation as seen from the endocardium. METHODS AND
resultsHuman hearts (n = 7) were acquired for imaging the left atrium with OCT. A spectral-domain OCT system with 1325 nm center wavelength, 6.5 μm axial resolution, 15 μm lateral resolution, and a maximum imaging depth of 2.51 mm in the air was used. Large-scale OCT image maps of human left atrial tissue were developed, with adipose thickness and fiber orientation extracted from the imaging data. OCT imaging showed scattered distributions of adipose tissue around the septal and pulmonary vein regions, up to a depth of about 0.43 mm from the endocardial surface. The total volume of adipose tissue detected by OCT over one left atrium ranged from 1.42 to 28.74 mm
conclusionOCT imaging could provide adjunctive information on the distribution of subendocardial adipose tissue, particularly around thin areas around the pulmonary veins and septal regions. Variations in OCT-detected tissue composition could potentially assist ablation guidance.
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