ArticleeLife2019
TMC1 is an essential component of a leak channel that modulates tonotopy and excitability of auditory hair cells in mice.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Molecular identity of the mechanotransduction machinery in inner ear hair cells and mechanotransduction-linked hearing loss.Fundamental research · 2026Review
- Cochlear Implantation Outcomes in Genotyped Subjects with Sensorineural Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- A force-sensitive adhesion GPCR is required for equilibrioception.Cell research · 2025Article
- Sequence variations and accessory proteins adapt TMC functions to distinct sensory modalities.Neuron · 2024Article
- Priming central sound processing circuits through induction of spontaneous activity in the cochlea before hearing onset.Trends in neurosciences · 2024Review
- CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway inScience advances · 2022Article
- Review
- Article
- Prestin-Mediated Frequency Selectivity Does not Cover Ultrahigh Frequencies in Mice.Neuroscience bulletin · 2022Article
- Mechanotransduction in mammalian sensory hair cells.Molecular and cellular neurosciences · 2022Review
- Article
- TMC4 is a novel chloride channel involved in high-concentration salt taste sensation.The journal of physiological sciences : JPS · 2021Article
- PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Mechanisms in cochlear hair cell mechano-electrical transduction for acquisition of sound frequency and intensity.Cellular and molecular life sciences : CMLS · 2021Review
- The Mechanosensory Transduction Machinery in Inner Ear Hair Cells.Annual review of biophysics · 2021Review
- Article
- TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells.Neuron · 2020Article
- Recent advances in cochlear hair cell nanophysiology: subcellular compartmentalization of electrical signaling in compact sensory cells.Faculty reviews · 2020Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Hearing sensation relies on the mechano-electrical transducer (MET) channel of cochlear hair cells, in which transmembrane channel-like 1 (TMC1) and transmembrane channel-like 2 (TMC2) have been proposed to be the pore-forming subunits in mammals. TMCs were also found to regulate biological processes other than MET in invertebrates, ranging from sensations to motor function. However, whether TMCs have a non-MET role remains elusive in mammals. Here, we report that in mouse hair cells, TMC1, but not TMC2, provides a background leak conductance, with properties distinct from those of the MET channels. By cysteine substitutions in TMC1, we characterized four amino acids that are required for the leak conductance. The leak conductance is graded in a frequency-dependent manner along the length of the cochlea and is indispensable for action potential firing. Taken together, our results show that TMC1 confers a background leak conductance in cochlear hair cells, which may be critical for the acquisition of sound-frequency and -intensity.
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