ArticleeLife2019
Cerebellar climbing fibers encode expected reward size.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- The Human Cerebellum Encodes Temporally Sensitive Reinforcement Learning Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cerebellar Time and Relative Time: A Comparator-Based Dynamical Timing Model and its Relevance to Psychopathology and Therapies.Cerebellum (London, England) · 2026Review
- Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026Review
- Sustained visual signals in the primate cerebellar dentate nucleus drive associative learning.Communications biology · 2025Article
- Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning.Current biology : CB · 2025Article
- The human cerebellum encodes temporally sensitive reinforcement learning signals.bioRxiv : the preprint server for biology · 2025Article
- A cerebello-thalamo-cortical pathway transmits reward-based post-error signals for motor timing correction during learning in male mice.Nature communications · 2025Article
- Reward-driven cerebellar climbing fiber activity influences both neural and behavioral learning.bioRxiv : the preprint server for biology · 2025Article
- Predictive reward-prediction errors of climbing fiber inputs integrate modular reinforcement learning with supervised learning.PLoS computational biology · 2025Article
- Cerebellar control of targeted tongue movements.The Journal of physiology · 2025Article
- Neural circuit mechanisms to transform cerebellar population dynamics for motor control in monkeys.bioRxiv : the preprint server for biology · 2025Article
- Social and emotional learning in the cerebellum.Nature reviews. Neuroscience · 2024Review
- Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice.Cerebellum (London, England) · 2024Review
- Article
- A cerebellar granule cell-climbing fiber computation to learn to track long time intervals.Neuron · 2024Article
- The Role of the Cerebellum in Learning to Predict Reward: Evidence from Cerebellar Ataxia.Cerebellum (London, England) · 2024Article
- Reinforcement Motor Learning After Cerebellar Damage Is Related to State Estimation.Cerebellum (London, England) · 2024Article
- Purkinje cell dysfunction causes disrupted sleep in ataxic mice.Disease models & mechanisms · 2024Article
- Inhibiting cholinergic signalling in the cerebellar interpositus nucleus impairs motor behaviour.The European journal of neuroscience · 2024Article
- Re-examining the Mysterious Role of the Cerebellum in Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently, evidence has accumulated to suggest that the cerebellum is also involved in the processing of reward. To study how rewarding events are encoded, we recorded the activity of climbing fibers when monkeys were engaged in an eye movement task. At the beginning of each trial, the monkeys were cued to the size of the reward that would be delivered upon successful completion of the trial. Climbing fiber activity increased when the monkeys were presented with a cue indicating a large reward, but not a small reward. Reward size did not modulate activity at reward delivery or during eye movements. Comparison between climbing fiber and simple spike activity indicated different interactions for coding of movement and reward. These results indicate that climbing fibers encode the expected reward size and suggest a general role of the cerebellum in associative learning beyond error correction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.