ArticleActa neuropathologica communications2019
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Article in Acta neuropathologica communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- 18F-Flortaucipir (AV1451) imaging identifies grey matter atrophy in retired athletes.Journal of neurology · 2024Article
- Clinical Outcomes and Tau Pathology in Retired Football Players: Associations With Diagnosed and Witnessed Sleep Apnea.Neurology. Clinical practice · 2024Article
- Head-to-head comparison of [Acta neuropathologica · 2024Article
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- Tau Positron Emission Tomography and Neurocognitive Function Among Former Professional American-Style Football Players.Journal of neurotrauma · 2023Article
- Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir.Journal of molecular biology · 2023Article
- Evaluation of Tau Radiotracers in Chronic Traumatic Encephalopathy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Thioflavin S Staining and Amyloid Formation Are Unique to Mixed Tauopathies.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2023Article
- Traumatic brain injury and the pathways to cerebral tau accumulation.Frontiers in neurology · 2023Review
- Brain Trauma Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Positron emission tomography imaging for the assessment of mild traumatic brain injury and chronic traumatic encephalopathy: recent advances in radiotracers.Neural regeneration research · 2022Article
- Characterization of neuroinflammatory positron emission tomography biomarkers in chronic traumatic encephalopathy.Brain communications · 2022Article
- The Legacy of the TTASAAN Report - Premature Conclusions and Forgotten Promises About SPECT Neuroimaging: A Review of Policy and Practice Part II.Frontiers in neurology · 2022Article
- Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project.Alzheimer's research & therapy · 2021Article
- Identifying degenerative effects of repetitive head trauma with neuroimaging: a clinically-oriented review.Acta neuropathologica communications · 2021Review
- Neuroimaging Biomarkers of Chronic Traumatic Encephalopathy: Targets for the Academic Memory Disorders Clinic.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- A critical review of radiotracers in the positron emission tomography imaging of traumatic brain injury: FDG, tau, and amyloid imaging in mild traumatic brain injury and chronic traumatic encephalopathy.European journal of nuclear medicine and molecular imaging · 2021Review
- Tauvid™: The First FDA-Approved PET Tracer for Imaging Tau Pathology in Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Head injury is associated with tau deposition on PET in MCI and AD patients.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Interaction of APOE4 alleles and PET tau imaging in former contact sport athletes.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
introductionChronic traumatic encephalopathy (CTE) is a tauopathy associated to repetitive head trauma. There are no validated in vivo biomarkers of CTE and a definite diagnosis can only be made at autopsy. Recent studies have shown that positron emission tomography (PET) tracer AV-1451 (Flortaucipir) exhibits high binding affinity for paired helical filament (PHF)-tau aggregates in Alzheimer (AD) brains but relatively low affinity for tau lesions in other tauopathies like temporal lobal degeneration (FTLD)-tau, progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD). Little is known, however, about the binding profile of this ligand to the tau-containing lesions of CTE.
objectiveTo study the binding properties of [
methodsWe performed [
resultsDespite the presence of abundant tau aggregates in multiple regions in all CTE brains, only faint or no [
conclusionAV-1451 may have limited utility for in vivo selective and reliable detection of tau aggregates in CTE. The existence of disease-specific tau conformations may likely explain the differential binding affinity of this tracer for tau lesions in different tauopathies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.