Evidence map›Paper›PMID 31660999›Full record

ArticleParticle and fibre toxicology2019

Role of chemical composition and redox modification of poorly soluble nanomaterials on their ability to enhance allergic airway sensitisation in mice.

Susan Dekkers, James G Wagner, Rob J Vandebriel, Elyse A Eldridge, Selina V Y Tang, Mark R Miller, Isabella Römer, Wim H de Jong, Jack R Harkema, Flemming R Cassee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Particle and fibre toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. The MAK collection for occupational health and safety · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Susan DekkersNational Institute for Public Health and the Environment (RIVM), P.O.Box 1, 3720 BA, Bilthoven, The Netherlands. susan.dekkers@rivm.nl.ORCID 0000-0003-2528-863X
James G WagnerDepartment of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA.
Rob J VandebrielNational Institute for Public Health and the Environment (RIVM), P.O.Box 1, 3720 BA, Bilthoven, The Netherlands.
Elyse A EldridgeDepartment of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA.
Selina V Y TangPromethean Particles Ltd, Nottingham, UK.
Mark R MillerCentre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Isabella RömerSchool of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham, UK.
Wim H de JongNational Institute for Public Health and the Environment (RIVM), P.O.Box 1, 3720 BA, Bilthoven, The Netherlands.
Jack R HarkemaDepartment of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, USA.
Flemming R CasseeNational Institute for Public Health and the Environment (RIVM), P.O.Box 1, 3720 BA, Bilthoven, The Netherlands.
Michigan State University · USNational Institute for Public Health and the Environment · NLPromethean Particles (United Kingdom) · GBUniversity of Birmingham · GBUniversity of Edinburgh · GBUtrecht University · NL

Funding

British Heart Foundation SP/15/8/31575
6 · The paper itself

Abstract

backgroundEngineered nanoparticles (NPs) have been shown to enhance allergic airways disease in mice. However, the influence of the different physicochemical properties of these particles on their adjuvant properties is largely unknown. Here we investigate the effects of chemical composition and redox activity of poorly soluble NPs on their adjuvant potency in a mouse model of airway hypersensitivity.

resultsNPs of roughly similar sizes with different chemical composition and redox activity, including CeO

conclusionsThe findings indicate that chemical composition of NPs influences both the relative potency of NPs to exacerbate allergic airway sensitization and the type of immune response. However, no relation between the acellular redox activity and the observed adjuvant activity of the different NPs was found. Further research is needed to pinpoint the precise physiological properties of NPs and biological mechanisms determining adjuvant activity in order to facilitate a safe-by-design approach to NP development.

Indexed as

Administration, IntranasalAnimalsBronchoalveolar Lavage FluidImmunoglobulin EImmunoglobulin GInterleukinsLungMiceMice, Inbred BALB CNanostructuresOvalbuminOxidation-ReductionRespiratory HypersensitivitySolubilityImmunoglobulin EImmunoglobulin GInterleukinsOvalbuminAdjuvantAllergy, Poorly solubleCobalt oxide, Cerium dioxideNanomaterialsRedox activity

Identifiers

PMID31660999
PMCPMC6819391
OpenAlexW2982578080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.