ArticleBreast cancer research : BCR2019
Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer.
Article in Breast cancer research : BCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Repeated measures of mammographic density and texture to evaluate prediction and risk of breast cancer: a systematic review of the methods used in the literature.Cancer causes & control : CCC · 2023Pooled it
- Development of a prognostic model for preoperative stage I-III breast cancer using machine learning with integrated cone-beam breast computed tomography data.La Radiologia medica · 2026Article
- Longitudinal changes in mammographic density and reproductive hormones during the menopausal transition in middle-aged Korean women: effect modification by obesity.Breast cancer research : BCR · 2025Article
- Mammographic density by time and breast: a retrospective cohort study from BreastScreen Norway.Breast cancer research : BCR · 2025Article
- Assessment of Volumetric Dense Tissue Segmentation in Tomosynthesis Using Deep Virtual Clinical Trials.Pattern recognition · 2024Article
- Association and Prediction Utilizing Craniocaudal and Mediolateral Oblique View Digital Mammography and Long-Term Breast Cancer Risk.Cancer prevention research (Philadelphia, Pa.) · 2023Article
- Changes in mammographic density and risk of breast cancer among a diverse cohort of women undergoing mammography screening.Breast cancer research and treatment · 2023Article
- Fully Automated Volumetric Breast Density Estimation from Digital Breast Tomosynthesis.Radiology · 2021Article
- Article
- Medication use and mammographic breast density.Breast cancer research and treatment · 2021Article
- Gut microbiome, body weight, and mammographic breast density in healthy postmenopausal women.Cancer causes & control : CCC · 2021Article
- Mammography features for early markers of aggressive breast cancer subtypes and tumor characteristics: A population-based cohort study.International journal of cancer · 2021Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundGiven that breast cancer and normal dense fibroglandular tissue have similar radiographic attenuation, we examine whether automated volumetric density measures identify a differential change between breasts in women with cancer and compare to healthy controls.
methodsEligible cases (n = 1160) had unilateral invasive breast cancer and bilateral full-field digital mammograms (FFDMs) at two time points: within 2 months and 1-5 years before diagnosis. Controls (n = 2360) were matched to cases on age and date of FFDMs. Dense volume (DV) and volumetric percent density (VPD) for each breast were assessed using Volpara™. Differences in DV and VPD between mammograms (median 3 years apart) were calculated per breast separately for cases and controls and their difference evaluated by using the Wilcoxon signed-rank test. To simulate clinical practice where cancer laterality is unknown, we examined whether the absolute difference between breasts can discriminate cases from controls using area under the ROC curve (AUC) analysis, adjusting for age, BMI, and time.
resultsAmong cases, the VPD and DV between mammograms of the cancerous breast decreased to a lesser degree (- 0.26% and - 2.10 cm
conclusionThere is a small relative increase in volumetric density measures over time in the breast with cancer which is not found in the normal breast. However, the magnitude of this difference is small, and this measure alone does not appear to be a good discriminator between women with and without breast cancer.
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