Evidence map›Paper›PMID 31660903›Full record

ArticleBMC cancer2019

Predictive factors of disease-free survival after complete pathological response to neoadjuvant radiotherapy for rectal adenocarcinoma: retrospective case series.

Amine Souadka, Mohammed Anass Majbar, Amine Benkabbou, Badr Serji, Tarik Souiki, Sidi Mohammed Bouchentouf, Mourad Abid, Basma El Khannousi, Tijani El Harroudi, Hadj Omar El Malki and 10 more

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03601689 (Predictive Factors of Disease-free Survival After Complete Pathological Response to Neoadjuvant Radiotherapy in Rectal Adenocarcinoma), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03601689 completednot on this map

Predictive Factors of Disease-free Survival After Complete Pathological Response to Neoadjuvant Radiotherapy in Rectal Adenocarcinoma

TypeobservationalSponsorMoroccan Society of SurgeryRan2005 to 2016Enrolled84ConditionsRectal NeoplasmsArmsrectal resection
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 3 countries.

Amine SouadkaSurgical Oncology Department, National Institute of Oncology, Mohammed V University Medical School, Rabat, Morocco. a.souadka@um5s.net.ma.ORCID http://orcid.org/0000-0002-1091-9446
Mohammed Anass MajbarSurgical Oncology Department, National Institute of Oncology, Mohammed V University Medical School, Rabat, Morocco.
Amine BenkabbouSurgical Oncology Department, National Institute of Oncology, Mohammed V University Medical School, Rabat, Morocco.
Badr SerjiSurgical Oncology, Hospital El Farabi, Mohammed Ist University, Oujda, Morocco.
Tarik SouikiSurgery Department, Sidi Mohammed Ben Abdellah University, Fes, Morocco.
Sidi Mohammed BouchentoufSurgery Department, Military Hospital, Rabat, Morocco.
Mourad AbidBatna Anticancer Center Alger, Batna, Algeria.
Basma El KhannousiAnatomopathology Department, National Institute of Oncology, Rabat, Morocco.
Tijani El HarroudiSurgical Oncology, Hospital El Farabi, Mohammed Ist University, Oujda, Morocco.
Hadj Omar El MalkiSurgical Department "A", Ibn Sina Hospital, Rabat, Morocco.
Mohammed RaissAnatomopathology Department, National Institute of Oncology, Rabat, Morocco.
Lahsen IfrineSurgical Department "A", Ibn Sina Hospital, Rabat, Morocco.
Khalid MazazSurgery Department, Sidi Mohammed Ben Abdellah University, Fes, Morocco.
Aziz ZentarSurgery Department, Military Hospital, Rabat, Morocco.
Raouf MohsineSurgical Oncology Department, National Institute of Oncology, Mohammed V University Medical School, Rabat, Morocco.
Abdelilah SouadkaPrivate surgical oncology center, Salé, Morocco.
Abdelkader BelkouchiSurgical Department "A", Ibn Sina Hospital, Rabat, Morocco.
Mohammed Ahallat
Abdelmalek HroraSurgical Oncology Department, National Institute of Oncology, Mohammed V University Medical School, Rabat, Morocco.
Moroccan Society of Surgery
Mohammed V University · MAHôpital Ibn Sina-Rabat · MACentre Hospitalier Ibn Sina · MAHôpital Militaire Moulay Ismail · MAUniversity of Batna 1 · DZInstitut National d'Oncologie · MASidi Mohamed Ben Abdellah University · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany data suggest that patients with low rectal adenocarcinoma who achieved ypT0N0 status have improved survival and disease-free survival (DFS) compared to all other stages however only few data are available regarding the specific prognosis factors of this subgroup. This study aimed to evaluate predictive factors for disease free survival after complete pathological response (CPR) in cases of low rectal adenocarcinoma. MATERIALS AND

methodsFrom January 2005 to December 2013, all patients with low rectal adenocarcinoma who underwent neoadjuvant chemoradiotherapy followed by total mesorectal excision and achieved CPR were included at 7 Moroccan and 1 Algerian centres. Predictive factors for disease-free survival were analysed by uni and multivariate analysis.

resultsEigthy-four (12.1%) patients achieved a CPR (ypT0N0). Multivariate analysis revealed that both poorly differentiated tumors (OR, 9.23; 95 CI 1.35-62.82; P = 0.023) and the occurrence of perineal sepsis (OR, 13.51; 95 CI 1.96-93.12; P = 0.008) were independently associated with impaired DFS.

conclusionsPatients with low rectal cancer who exhibited a CPR after neoadjuvant therapy have good prognoses; however, the occurrence of perineal sepsis and/or poor initial differentiation may be associated with impaired DFS in these patients.

trial registrationThe study was retrospectively registered the 28th July 2018 in ClinicalTrials.gov register with the reference NCT03601689.

Indexed as

AdenocarcinomaAdultAgedChemoradiotherapyDisease-Free SurvivalFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedNeoadjuvant TherapyNeoplasm Recurrence, LocalNeoplasm StagingPerineumPrognosisComplete pathological responseDisease-free survivalNeoadjuvant treatmentPredictive factorsRectal neoplasm

Identifiers

PMID31660903
PMCPMC6816192
OpenAlexW2981895112

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.