Evidence map›Paper›PMID 31660894›Full record

ArticleBMC cancer2019

SUPR-3D: A randomized phase iii trial comparing simple unplanned palliative radiotherapy versus 3d conformal radiotherapy for patients with bone metastases: study protocol.

Robert Olson, Roel Schlijper, Nick Chng, Quinn Matthews, Marco Arimare, Lindsay Mathews, Fred Hsu, Tanya Berrang, Alexander Louie, Benjamin Mou and 5 more

Registry-linked trialOpen access · goldAbstract readClinical Trial ProtocolComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03694015 (SUPR-3D), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03694015 naterminatednot on this map

SUPR-3D: A Randomized Phase III Trial Comparing Simple Unplanned Palliative Radiotherapy Versus 3D Conformal Radiotherapy for Patients With Bone Metastases

TypeinterventionalSponsorBritish Columbia Cancer AgencyRan2019 to 2026Enrolled160ConditionsNeoplasm Metastasis, Neoplastic Processes, Neoplasms, Pathologic ProcessesArmsSUPR, VMAT
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Evaluation of results and costs of high precision radiotherapy (VMAT) compared with conventional radiotherapy (3D) in the treatment of cancer patients with spinal cord compression of metastatic origin.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Robert OlsonUniversity of British Columbia, Vancouver, Canada. rolson2@bccancer.bc.ca.ORCID http://orcid.org/0000-0003-4532-6197
Roel SchlijperUniversity of British Columbia, Vancouver, Canada.
Nick ChngDepartment of Radiation Oncology, BC Cancer, 1215 Lethbridge Street, Prince George, BC, V2M7A9, Canada.
Quinn MatthewsDepartment of Radiation Oncology, BC Cancer, 1215 Lethbridge Street, Prince George, BC, V2M7A9, Canada.
Marco ArimareUniversity of Northern British Columbia, Prince George, Canada.
Lindsay MathewsUniversity of Northern British Columbia, Prince George, Canada.
Fred HsuBC Cancer, Abbotsford, Canada.
Tanya BerrangBC Cancer, Victoria, Canada.
Alexander LouieSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Benjamin MouBC Cancer, Kelowna, Canada.
Boris ValevDepartment of Radiation Oncology, BC Cancer, 1215 Lethbridge Street, Prince George, BC, V2M7A9, Canada.
Joanna LabaLondon Health Sciences Centre, London, Ontario, Canada.
David PalmaLondon Health Sciences Centre, London, Ontario, Canada.
Devin SchellenbergBC Cancer Surrey, Surrey, British Columbia, Canada.
Shilo LefresneUniversity of British Columbia, Vancouver, Canada.
London Health Sciences Centre · CAUniversity of British Columbia · CAUniversity of Northern British Columbia · CABC Cancer Agency · CAKelowna General Hospital · CASpinal Cord Injury BC · CASunnybrook Health Science Centre · CASurrey Memorial Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that high rates of RINV occur in part because of the widespread use of inexpensive simple unplanned palliative radiotherapy (SUPR), over more complex and resource intensive 3D conformal RT, such as volumetric modulated arc therapy (VMAT).

methodsThis is a randomized, multi-centre phase III trial of SUPR versus VMAT. We will accrue 250 patients to assess the difference in patient-reported RINV. This study is powered to detect a difference in quality of life between patients treated with VMAT vs. SUPR. DISCUSSION: This trial will determine if VMAT reduces early toxicity compared to SUPR and may provide justification for this more resource-intensive and costly form of RT.

trial registrationClinicaltrials.gov identifier: NCT03694015 . Date of registration: October 3, 2018.

Indexed as

Bone NeoplasmsPalliative CareRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedAdolescentAdultAgedAged, 80 and overClinical Trials, Phase III as TopicFemaleFollow-Up StudiesHumansMaleMiddle AgedMulticenter Studies as TopicNauseaBone metastasesQuality of lifeRadiation-induced nausea and vomitingRadiotherapy

Identifiers

PMID31660894
PMCPMC6819327
OpenAlexW2981848714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.