SynthesisBMC pregnancy and childbirth2019
Effect of interpregnancy weight change on perinatal outcomes: systematic review and meta-analysis.
Synthesis in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Pooled it
- Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis.Scientific reports · 2021Pooled it
- Change in modifiable maternal characteristics and behaviours between consecutive pregnancies and offspring adiposity: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Pooled it
- Prepregnancy body mass index and gestational weight gain are associated with maternal and infant adverse outcomes in Chinese women with gestational diabetes.Scientific reports · 2022Trial
- Trial
- Preconception Weight Loss to Prevent Childhood Obesity: Current Evidence and Research Gaps.Current obesity reports · 2026Review
- Are Peripartum Changes in CCL2 Associated with Maternal Metabolic Status?Current issues in molecular biology · 2026Article
- Maternal Prepregnancy Overweight: Associations With Maternal and Offspring Weight 4-7 Years Postpartum.Journal of diabetes research · 2026Article
- Maternal and Interpregnancy Factors and Risks of First-Time Preeclampsia in Second Pregnancy: A Swedish National Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Examining Interpregnancy Weight Change Across a Birthing Population in Aotearoa, New Zealand.The Australian & New Zealand journal of obstetrics & gynaecology · 2025Article
- Maternal outcomes among women with intellectual disabilities in comparison with the general population (IDcare).AJOG global reports · 2025Article
- A Smartphone App (PRIMI) to Promote Healthy Diet, Physical Activity, and Health Literacy After Childbirth Among Migrant Women: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2025Article
- Interpregnancy Weight Change and Adverse Birth Outcomes: Cohort Study Using Brazil's Routine Register-Based Linked Data.Maternal & child nutrition · 2025Article
- Which dietary pattern should be adopt by age-appropriate pregnant women to avoid gestational weight gain and gestational diabetes mellitus.BMC pregnancy and childbirth · 2025Article
- Article
- Relation between low birth weight or maternal obesity during pregnancy and cardiovascular risk factors.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Interpregnancy maternal weight change is not associated with offspring weight and obesity at age 2 years.International journal of obesity (2005) · 2024Article
- Postpartum and interpregnancy care of women with a history of hypertensive disorders of pregnancy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Practical weight management to minimize pregnancy complications and promote women's health: the possibility of interpregnancy care.Nagoya journal of medical science · 2024Review
- Neurodevelopmental Programming of Adiposity: Contributions to Obesity Risk.Endocrine reviews · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlthough obesity is a well-known risk factor for adverse pregnancy outcomes, evidence is sparse about the effects of interpregnancy weight change on the risk of adverse perinatal complications in a subsequent pregnancy. The current study aims to assess the effect of interpregnancy weight change on the risk of developing gestational diabetes, pre-eclampsia, pregnancy induced hypertension, preterm birth, or delivering a large- or small-for-gestational age neonate.
methodsPubmed, Ovid Embase, ClinicalTrial.gov and the Cochrane library were systematically searched up until July 24th, 2019. Interpregnancy weight change was defined as the difference between pre-pregnancy weight of an index pregnancy and a consecutive pregnancy. Inclusion criteria included full text original articles reporting quantitative data about interpregnancy weight change in multiparous women with any time interval between consecutive births and the risk of any perinatal complication of interest. Studies reporting adjusted odds ratios and a reference group of - 1 to + 1 BMI unit change between pregnancies were harmonised by meta-analysis.
resultsTwenty-three cohort studies identified a total of 671,906 women with two or more consecutive pregnancies. Seven of these studies were included in the meta-analysis (280,672 women). Interpregnancy weight gain was consistently associated with a higher risk of gestational diabetes, pre-eclampsia, pregnancy induced hypertension and large-for-gestational age births. In contrast, interpregnancy weight loss was associated with a lower risk of delivering a large-for-gestational age neonate. The effect magnitude (relative risk) of interpregnancy weight gain on pregnancy induced hypertension or delivering a large-for-gestational age neonate was greater among women with a normal BMI in the index pregnancy compared to women with a starting BMI ≥25 kg/m
conclusionThese findings confirm that interpregnancy weight change impacts the risk of developing perinatal complications in a subsequent pregnancy. This provides evidence in support of guidelines encouraging women to achieve post-partum weight loss, as their risk of perinatal complications might be minimised if they return to their pre-pregnancy weight before conceiving again. Prospectively registered with PROSPERO (CRD42017067326).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.