ArticleBMC infectious diseases2019
Clinical characteristics of acute Q fever patients in South Korea and time from symptom onset to serologic diagnosis.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 16 citations in OpenAlex.
- Clinical value of metagenomic next-generation sequencing in diagnosis of Coxiella burnetii infection.BMC infectious diseases · 2025Article
- Diagnosing and Preventing Q Fever in Regional New South Wales, Australia-A Qualitative Exploration of Perspectives of General Practitioners.The Australian journal of rural health · 2025Article
- Prevalence of Acute Q Fever Among High-Risk Patients With Fever and Pneumonia Symptoms in Western Iran.Journal of tropical medicine · 2025Article
- Acute Q fever in patients with an influenza-like illness in regional New South Wales, Australia.PLoS neglected tropical diseases · 2024Article
- AcuteOpen forum infectious diseases · 2024Article
- Current Status of Q Fever and the Challenge of Outbreak Preparedness in Korea: One Health Approach to Zoonoses.Journal of Korean medical science · 2023Review
- Performance Evaluation and Validation of Air Samplers To Detect Aerosolized Coxiella burnetii.Microbiology spectrum · 2022Article
- Shedding and extensive and prolonged environmental contamination of goat farms of Q fever patients by Coxiella burnetii.Veterinary medicine and science · 2022Article
- Seroepidemiologic evidence of Q fever and associated factors among workers in veterinary service laboratory in South Korea.PLoS neglected tropical diseases · 2022Article
- Case Report: Metagenomic Next-Generation Sequencing Clinches the Diagnosis of Acute Q Fever and Verified by Indirect Immunofluorescence Assay.Frontiers in medicine · 2022Article
- Seroreactivity toPathogens (Basel, Switzerland) · 2021Article
- Epidemiological investigation and physician awareness regarding the diagnosis and management of Q fever in South Korea, 2011 to 2017.PLoS neglected tropical diseases · 2021Article
- Isolation of Coxiella burnetii in patients with nonspecific febrile illness in South Korea.BMC infectious diseases · 2020Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute Q fever usually presents as a nonspecific febrile illness, and its occurrence is rapidly increasing in South Korea. This study investigated the clinical characteristics of acute Q fever patients in South Korea and the time from symptom onset to serologic diagnosis. The clinical courses were examined according to antibiotic treatment.
methodsData of patients diagnosed with acute Q fever at Chungbuk National University Hospital between January 2015 and February 2018 were retrospectively collected. Demographic and epidemiologic data were reviewed. The time from symptom onset to serologic diagnosis by an immunofluorescence assay (IFA) was analyzed. Clinical courses and the percentage of patients with a high phase I immunoglobulin G titer (≥ 1:1024) were compared between patients administered antibiotics with anti-Coxiella burnetii activity and patients not administered such antibiotics.
resultsForty-eight patients (median age: 51.5 years) were included. Most were male (95.8%) and had no history of animal contact (91.7%). The median time from illness onset to serologic diagnosis was 21 days. Thirty-nine patients received antibiotics with anti-C. burnetii activity. The length of hospital stay and fever duration did not significantly differ between patients who received antibiotics with anti-C. burnetii activity (7 and 15 days) and those who did not (5 and 8 days) (P = 0.110 and P = 0.137, respectively). The percentage of patients with a high phase I immunoglobulin G titer (≥ 1:1024) did not significantly differ between patients who received antibiotics with anti-C. burnetii activity and those who did not (P = 0.340).
conclusionsMost acute Q fever patients had a nonspecific febrile illness with mild elevation of transaminases and no history of animal contact or occupational risk. The time from symptom onset to a positive IFA test was longer than the fever duration in most acute Q fever patients. Consequently, it may be difficult for clinicians to serologically diagnose acute Q fever. However, inappropriate antibiotic treatment was not associated with prolongation of symptoms or progression to chronic Q fever.
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