Evidence map›Paper›PMID 31660849›Full record

ArticleBMC bioinformatics2019

Computational prediction of MoRFs based on protein sequences and minimax probability machine.

Hao He, Jiaxiang Zhao, Guiling Sun

Abstract read
In one paragraph

Article in BMC bioinformatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Computational prediction of disordered binding regions.Computational and structural biotechnology journal · 2023
    Review
  4. Review
  5. Predicting Protein Conformational Disorder and Disordered Binding Sites.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hao HeCollege of Electronic Information and Optical Engineering, Nankai University, Tianjin, China.
Jiaxiang ZhaoCollege of Electronic Information and Optical Engineering, Nankai University, Tianjin, China. zhaojx@nankai.edu.cn.ORCID http://orcid.org/0000-0002-2287-0811
Guiling SunCollege of Electronic Information and Optical Engineering, Nankai University, Tianjin, China.

Funding

National Natural Science Foundation of China 61771262
6 · The paper itself

Abstract

backgroundMolecular recognition features (MoRFs) are one important type of disordered segments that can promote specific protein-protein interactions. They are located within longer intrinsically disordered regions (IDRs), and undergo disorder-to-order transitions upon binding to their interaction partners. The functional importance of MoRFs and the limitation of experimental identification make it necessary to predict MoRFs accurately with computational methods.

resultsIn this study, a new sequence-based method, named as MoRF

conclusionsThe features used in MoRF

Indexed as

AlgorithmsAmino Acid SequenceProbabilityProteinsSoftwareProteinsIntrinsically disordered proteinsMinimax probability machineMolecular recognition features

Identifiers

PMID31660849
PMCPMC6819637

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.