Evidence map›Paper›PMID 31660741›Full record

ArticleJournal of the American Chemical Society2019

A Conformationally Restricted Aza-BODIPY Platform for Stimulus-Responsive Probes with Enhanced Photoacoustic Properties.

Effie Y Zhou, Hailey J Knox, Chang Liu, Weili Zhao, Jefferson Chan

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

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  15. A Highly Fluorescent Dinuclear Aluminium Complex with Near-Unity Quantum Yield.Angewandte Chemie (International ed. in English) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Effie Y ZhouDepartment of Chemistry and Beckman Institute for Advanced Science and Technology , University of Illinois at Urbana-Champaign , Urbana , Illinois 61801 , United States.ORCID 0000-0002-2222-7391
Hailey J KnoxDepartment of Chemistry and Beckman Institute for Advanced Science and Technology , University of Illinois at Urbana-Champaign , Urbana , Illinois 61801 , United States.ORCID 0000-0003-0608-2855
Chang LiuSchool of Pharmacy, Institutes of Integrative Medicine , Fudan University , Shanghai , 201203 , P. R. China.
Weili ZhaoSchool of Pharmacy, Institutes of Integrative Medicine , Fudan University , Shanghai , 201203 , P. R. China.ORCID 0000-0001-9403-1382
Jefferson ChanDepartment of Chemistry and Beckman Institute for Advanced Science and Technology , University of Illinois at Urbana-Champaign , Urbana , Illinois 61801 , United States.ORCID 0000-0003-4139-4379

Funding

Training Program in Chemistry-Interface with BiologyT32GM070421 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL · 2005 to 2019
$5.4M
Tissue microenvironment (TIMe) training programT32EB019944 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BHARGAVA, ROHIT, GASKINS, REX · 2016 to 2025
$1.9M
NIBIB NIH HHS T32 EB019944NIGMS NIH HHS T32 GM070421
6 · The paper itself

Abstract

Photoacoustic (PA) dyes, which absorb near-infrared (NIR) light to generate an ultrasonic signal, can be detected at centimeter depths in tissues with significantly higher resolution than dyes imaged with fluorescence-based methods. As such, PA agents show great promise as research tools for the study of live-animal disease models. However, the development of activatable PA probes has been hampered by the relative scarcity of appropriate PA-active molecular platforms with properties that can be manipulated in a rational manner. Herein we synthesized and evaluated six modifications to the aza-BODIPY dye platform with respect to their absorbance, fluorescence, and PA properties. We identified a promising

Indexed as

AnimalsBoron CompoundsCell Line, TumorFemaleFluorescenceFluorescent DyesInfrared RaysMaleMice, Inbred BALB CMolecular ConformationNeoplasmsPhotoacoustic TechniquesazaBDPBA compoundBoron CompoundsFluorescent Dyes

Identifiers

PMID31660741
PMCPMC6942515

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.