ArticleACS central science2019
From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds.
Article in ACS central science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- The One-Step Synthesis of Biologically Active Isochromans from Lignin-Derived Aromatic Monomers in Tunable Deep Eutectic Solvents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Navigating the Forest of Lignin-Derived Monomers for Polymer Synthesis.Biomacromolecules · 2026Review
- Synthesis of bio-based N-containing compounds from biomass.National science review · 2025Review
- Modular synthetic routes to biologically active indoles from lignin.Green chemistry : an international journal and green chemistry resource : GC · 2025Article
- Synthesis of aromatic amides from lignin and its derivatives.Nature communications · 2025Article
- Benzenoid Aromatics from Renewable Resources.Chemical reviews · 2024Review
- Review
- Atomically dispersed cobalt catalysts for tandem synthesis of primary benzylamines from oxidized β-O-4 segments.Chemical science · 2024Article
- Bulky, electron-rich, renewable: analogues of Beller's phosphine for cross-couplings.Catalysis science & technology · 2023Article
- Towards bioresource-based aggregation-induced emission luminogens from lignin β-O-4 motifs as renewable resources.Nature communications · 2023Article
- Sustainable production of dopamine hydrochloride from softwood lignin.Nature communications · 2023Article
- Recent Advances in the Green Synthesis of ActivePharmaceuticals (Basel, Switzerland) · 2023Review
- High value valorization of lignin as environmental benign antimicrobial.Materials today. Bio · 2023Review
- Primary amines from lignocellulose by direct amination of alcohol intermediates, catalyzed by RANEY® Ni.Catalysis science & technology · 2022Article
- Degradation of Lignin by Infrared Free Electron Laser.Polymers · 2022Article
- Fully lignocellulose-based PET analogues for the circular economy.Nature communications · 2022Article
- Transition-metal-free synthesis of pyrimidines from lignin β-O-4 segments via a one-pot multi-component reaction.Nature communications · 2022Article
- A molecular motor from lignocellulose.Green chemistry : an international journal and green chemistry resource : GC · 2022Article
- Ambient-pressure lignin valorization to high-performance polymers by intensified reductive catalytic deconstruction.Science advances · 2022Article
- Oxidative Catalytic Fractionation of Lignocellulosic Biomass under Non-alkaline Conditions.Journal of the American Chemical Society · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inherently complex, lignin-derived aromatic monomers comprising valuable structural moieties present in many pharmaceuticals would serve as ideal substrates for the construction of biologically active molecules. Here, we describe a strategy that incorporates all intrinsic functional groups present in platform chemicals obtained by lignin depolymerization into value-added amines, using sustainable catalytic methods and benign solvents. Our strikingly efficient protocol provides access to libraries of aminoalkyl-phenol derivatives and seven-membered N-heterocycles directly from wood in two, respectively three, waste-free steps. Several molecules in these libraries have shown promising antibacterial or anticancer activities, emphasizing the advantage of this modular synthetic strategy and the potential for drug discovery. The sustainable catalytic pathways presented here can lead to significant benefits for the pharmaceutical industry where reduction of hazardous waste is a prime concern, and the described strategies that lead to high-value products from non-edible biomass waste streams also markedly increase the economic feasibility of lignocellulosic biorefineries.
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Registered trials
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