Evidence map›Paper›PMID 31660408›Full record

ArticleOpen forum infectious diseases2019

Bacteremia in Childhood Life-Threatening Infections in Urban Gambia: EUCLIDS in West Africa.

F Secka, J A Herberg, I Sarr, S Darboe, G Sey, M Saidykhan, M Wathuo, M Kaforou, M Antonio, A Roca and 15 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Microbiological Profiles and Inflammatory Biomarkers of Bacteremia in Children in a Teaching Hospital in Kuwait: An 8-Year Retrospective Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Impact of routine vaccination againstJournal of global health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 9 institutions in 6 countries.

F SeckaMedical Research Council The Gambia at London School of Hygiene & Tropical Medicine, United Kingdom.
J A HerbergImperial College London, Section of Paediatric Infectious Disease, United Kingdom.ORCID 0000-0001-6941-6491
I SarrMedical Research Council The Gambia at London School of Hygiene & Tropical Medicine, United Kingdom.
S DarboeMedical Research Council The Gambia at London School of Hygiene & Tropical Medicine, United Kingdom.
G SeyMedical Research Council The Gambia at London School of Hygiene & Tropical Medicine, United Kingdom.
M SaidykhanMedical Research Council The Gambia at London School of Hygiene & Tropical Medicine, United Kingdom.
M WathuoMedical Research Council The Gambia at London School of Hygiene & Tropical Medicine, United Kingdom.
M KaforouImperial College London, Section of Paediatric Infectious Disease, United Kingdom.
M AntonioMedical Research Council The Gambia at London School of Hygiene & Tropical Medicine, United Kingdom.
A RocaMedical Research Council The Gambia at London School of Hygiene & Tropical Medicine, United Kingdom.
S M A ZamanMedical Research Council The Gambia at London School of Hygiene & Tropical Medicine, United Kingdom.
M Cebey-LópezInstituto de Investigación Sanitaria de Santiago, Genetics-Vaccines-Infectious Diseases and Paediatrics Research Group, GENVIP, Spain.
N P BoeddhaErasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Intensive Care and Department of Paediatric Surgery, The Netherlands.
S PaulusUniversity of Liverpool Institute of Infection and Global Health, Department of Clinical Infection Microbiology and Immunology, United Kingdom.
D S KohlfürstMedical University of Graz, Department of General Paediatrics, Austria.
M EmontsInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
W ZenzMedical University of Graz, Department of General Paediatrics, Austria.
E D CarrolUniversity of Liverpool Institute of Infection and Global Health, Department of Clinical Infection Microbiology and Immunology, United Kingdom.
R de GrootPaediatric Infectious Diseases and Immunology, Amalia Children's Hospital, and Expertise Center for Immunodeficiency and Autoinflammation, and Section Paediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, and Radboud Center for Infectious Diseases, Radboudumc, Nijmegen, the Netherlands.
L SchlapbachUniversity Children's Hospital Zurich and the Children's Research Center, Switzerland.
F Martinon-TorresInstituto de Investigación Sanitaria de Santiago, Genetics-Vaccines-Infectious Diseases and Paediatrics Research Group, GENVIP, Spain.
K BojangMedical Research Council The Gambia at London School of Hygiene & Tropical Medicine, United Kingdom.
M LevinImperial College London, Section of Paediatric Infectious Disease, United Kingdom.
M van der FlierPaediatric Infectious Diseases and Immunology, Amalia Children's Hospital, and Expertise Center for Immunodeficiency and Autoinflammation, and Section Paediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, and Radboud Center for Infectious Diseases, Radboudumc, Nijmegen, the Netherlands.
S T AndersonMedical Research Council The Gambia at London School of Hygiene & Tropical Medicine, United Kingdom.
London School of Hygiene & Tropical Medicine · GBImperial College London · GBInstituto de Investigación Sanitaria de Santiago · ESMedical University of Graz · ATRadboud University Nijmegen · NLUniversity of Liverpool · GBErasmus MC - Sophia Children’s Hospital · NLNewcastle upon Tyne Hospital · GBUniversity Children's Hospital Zurich · CH

Funding

Medical Research Council MC_UP_A900_1118Wellcome Trust 206508/Z/17/Z
6 · The paper itself

Abstract

backgroundThe limited availability of microbiology services in sub-Saharan Africa impedes accurate diagnosis of bacterial pathogens and understanding of trends in prevalence and antibiotic sensitivities. We aimed to characterize bacteremia among hospitalized children in The Gambia and to identify factors associated with bacteremia and mortality.

methodsWe prospectively studied children presenting with suspected severe infection to 2 urban hospitals in The Gambia, between January 2013 and September 2015. Demographic and anthropometric data, clinical features, management, and blood culture results were documented. Urine screens for antibiotic activity were performed in a subset of participants.

resultsOf 411 children enrolled (median age, 29 months; interquartile range, 11-82), 79.5% (325 of 409) reported prehospital antibiotic use. Antimicrobial activity by urinary screen for antibiotic activity was detected in 70.8% (n = 80 of 113). Sixty-six bacterial pathogens were identified in 65 (15.8%) participants and

conclusionsThe bacteremia rate in children with suspected childhood life-threatening infectious diseases in The Gambia is high. The pattern of pathogen prevalence and antimicrobial resistance has changed over time compared with previous studies illustrating the importance of robust bacterial surveillance programs in resource-limited settings.

Indexed as

antibioticbacteremiachildrenGambiamortality

Identifiers

PMID31660408
PMCPMC6798247
OpenAlexW2890541940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.