Evidence map›Paper›PMID 31660407›Full record

ArticleOpen forum infectious diseases2019

Alexithymia Predicts Carotid Atherosclerosis, Vascular Events, and All-Cause Mortality in Human Immunodeficiency Virus-Infected Patients: An Italian Multisite Prospective Cohort Study.

Francesco Vadini, Federica Sozio, Giordano Madeddu, Giuseppe De Socio, Paolo Maggi, Giuseppe Nunnari, Francesca Vichi, Paola Di Stefano, Elisa Tracanna, Ennio Polilli and 9 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Examining Depression as a Risk Factor for Cardiovascular Disease in People with HIV: A Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023
    Pooled it
  2. Article
  3. Article
  4. Alexithymia and asthma: a systematic review.Frontiers in psychology · 2023
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 1 country.

Francesco VadiniInfectious Disease Unit, Pescara General Hospital, Italy.
Federica SozioInfectious Disease Unit, Pescara General Hospital, Italy.
Giordano MadedduDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Sassari, Italy.
Giuseppe De SocioInfectious Diseases Unit, Santa Maria Hospital, Perugia, Italy.
Paolo MaggiInfectious Diseases Clinic, Policlinico Hospital, Bari, Italy.
Giuseppe NunnariDepartment of Clinical and Experimental Medicine, University of Messina, Italy.
Francesca VichiInfectious Diseases Unit, Santa Maria Annunziata Hospital, Bagno a Ripoli, Florence, Italy.
Paola Di StefanoInfectious Disease Unit, Pescara General Hospital, Italy.
Elisa TracannaInfectious Disease Unit, Pescara General Hospital, Italy.
Ennio PolilliClinical Pathology Laboratory, Pescara General Hospital, Italy.
Antonina SciaccaInfectious Disease Unit, Pescara General Hospital, Italy.
Bernardetta ZiziDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Sassari, Italy.
Vincenzo LaiDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Sassari, Italy.
Claudio BartolozziInfectious Diseases Unit, Santa Maria Annunziata Hospital, Bagno a Ripoli, Florence, Italy.
Maria Elena FlaccoLocal Health Unit of Pescara, Italy.
Paolo BonfantiInfectious Diseases Unit, A. Manzoni Hospital, Lecco, Italy.
Francesca SantilliDepartment of Medicine and Aging and Center of Aging Science and Translational Medicine, University of Chieti, Italy.
Lamberto ManzoliDepartment of Medical Sciences, University of Ferrara, Italy.ORCID 0000-0002-8129-9344
Giustino ParrutiInfectious Disease Unit, Pescara General Hospital, Italy.
Azienda USL di Pescara · ITUniversity of Sassari · ITAlessandro Manzoni Hospital · ITUniversity of Chieti-Pescara · ITUniversity of Ferrara · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPsychological factors (PFs) are known predictors of cardiovascular disease (CVD) in many clinical settings, but data are lacking for human immunodeficiency virus (HIV) infection. We carried out a prospective study to evaluate (1) psychological predictors of preclinical and clinical vascular disease and (2) all-cause mortality (ACM) in HIV patients.

methodsWe conducted a cross-sectional analysis of baseline data to evaluate the predictors of carotid plaques (CPs) and a prospective analysis to explore predictors of vascular events (VEs) and ACM over 10 years. Human immunodeficiency virus patients monitored at the Infectious Disease Units of 6 Italian regions were consecutively enrolled. Traditional CVD risk factors, PFs (depressive symptoms, alexithymia, distress personality), and CPs were investigated. Vascular events and ACM after enrollment were censored at March 2018.

resultsA multicenter cohort of 712 HIV-positive patients (75.3% males, aged 46.1 ± 10.1 years) was recruited. One hundred seventy-five (31.6%) patients had CPs at baseline. At the cross-sectional analysis, alexithymia was independently associated with CPs (odds ratio, 4.93; 95% confidence interval [CI], 2.90-8.50;

conclusionsThe present results validate our previous monocentric finding. Alexithymia may be an additional tool for the multifactorial assessment of cardiovascular risk in HIV.

Indexed as

alexithymiaatherosclerosisHIVmortalitypsychological factors

Identifiers

PMID31660407
PMCPMC6761942
OpenAlexW2965197445

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.