ArticleOpen forum infectious diseases2019
Blurred Molecular Epidemiological Lines Between the Two Dominant Methicillin-Resistant
Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Polymicrobial methicillin-resistantMicrobiology spectrum · 2024Article
- Genomic analysis ofiScience · 2024Article
- Impact of Bicarbonate on PBP2a Production, Maturation, and Functionality in Methicillin-ResistantAntimicrobial agents and chemotherapy · 2023Article
- Bacterial distribution and drug resistance in blood samples of children in Jiangxi Region, 2017-2021.Frontiers in cellular and infection microbiology · 2023Article
- Methicillin-resistantAntimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Molecular Epidemiology, Antimicrobial Susceptibility, and Clinical Features of Methicillin-ResistantMicroorganisms · 2022Article
- What Is the Optimal Follow-up Length for Mortality inOpen forum infectious diseases · 2022Article
- Everybody nose: molecular and clinical characteristics of nasal colonization during active methicillin-resistant Staphylococcus aureus bloodstream infection.BMC infectious diseases · 2022Article
- PathoSPOT genomic epidemiology reveals under-the-radar nosocomial outbreaks.Genome medicine · 2020Article
- Article
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Authors and funding
18 authors.
Funding
Abstract
backgroundMethicillin-resistant
methodsComprehensive clinical data from the electronic health records of 227 hospitalized patients ≥18 years old with MRSA BSI over a 33-month period in New York City were collected. The descriptive epidemiology and mortality associated with the two dominant clones were compared using logistic regression.
resultsMolecular analysis revealed that 91% of all single-patient MRSA BSIs were due to two equally represented genotypes, clonal complex (CC) 5 (n = 117) and CC8 (n = 110). MRSA BSIs were associated with a 90-day mortality rate of 27%. CC8 caused disease more frequently in younger age groups (56 ± 17 vs 67 ± 17 years old;
conclusionsThe clinical features distinguishing dominant MRSA clones continue to converge. The association of CC8 with peripheral intravenous catheter infections underscores the importance of classical community clones causing hospital-onset infections. Ongoing monitoring and analysis of the dynamic epidemiology of this endemic pathogen are crucial to inform management and prevent disease.
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