ArticleOpen forum infectious diseases2019
Vitamin D and Acute Respiratory Infections-The PODA Trial.
Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01153568 (Vitamin D and Osteoporosis Prevention in Elderly African American Women), which is not on this map. Cited by 10 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vitamin D and Osteoporosis Prevention in Elderly African American Women: A 4-year Randomized, Double-blind, Placebo-controlled Study to Investigate the Effect of Vitamin D Status in Elderly African American Women
Who cites it
10 citing papers in PubMed, 5 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of stratified aggregate data.The lancet. Diabetes & endocrinology · 2025Pooled it
- Effect of vitamin D status and vitamin D supplementation on immune function and prevention of acute respiratory tract infections in dark-skinned individuals: a systematic review and meta-analysis.Public health nutrition · 2024Pooled it
- Optimal methods of vitamin D supplementation to prevent acute respiratory infections: a systematic review, dose-response and pairwise meta-analysis of randomized controlled trials.Nutrition journal · 2024Pooled it
- Vitamin D supplementation for prevention of acute respiratory infections in older adults: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis.BMJ global health · 2021Pooled it
- Trabecular bone score in PODA, a Randomized Controlled Trial (RCT) in older African American Women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Trial
- Comparative effectiveness of oral nutritional supplements in preventing respiratory tract infections among adults: a systematic review and network meta-analysis.EClinicalMedicine · 2025Article
- Vitamin D supplementation to prevent acute respiratory infections: systematic review and meta-analysis of aggregate data from randomised controlled trials.medRxiv : the preprint server for health sciences · 2020Article
- Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial.Nutrients · 2020Article
- Association Between Vitamin D and Novel SARS-CoV-2 Respiratory Dysfunction - A Scoping Review of Current Evidence and Its Implication for COVID-19 Pandemic.Frontiers in physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is considerable heterogeneity in clinical trials examining the role of vitamin D in the prevention of acute respiratory infections (ARIs).
methodsThe primary aim of the Physical Performance, Osteoporosis, and Vitamin D in Older African-American Women (PODA) trial was the prevention of bone loss and decline in physical performance. A questionnaire about ARIs was administered every 3 months for 3 years to 260 black American women in a double-blind randomized clinical trial that had a placebo group and a vitamin D supplementation group. The serum 25(OH)D level was maintained >30 ng/mL in the vitamin D group.
resultsSerum 25(OH)D was maintained >30 ng/mL in 90% of the active group, whereas levels approximated those associated with the recommended dietary allowance (20 ng/mL) in the placebo group. There was no difference in occurrence of ARIs in the treatment group vs the placebo group. ARIs were not related to total or free 25(OH)D, which were measured at baseline and annually for 36 months.
conclusionsVitamin D supplementation sufficient to maintain serum 25(OH)D >30 ng/mL does not prevent ARIs in older African American women. CLINICALTRIALSGOV REGISTRATION NUMBER: NCT01153568.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.