Evidence map›Paper›PMID 31660381›Full record

ArticleOpen forum infectious diseases2019

Pharmacokinetics and Pharmacodynamics of Conventional-Dose vs Triple-Dose Oseltamivir in Severely Immunocompromised Children With Influenza.

Francisco Bautista, Dan Engelhard, Carmelo Rizzari, Margarita Baka, Jesús Saavedra-Lozano, Eduardo Lopez-Medina, Clare Nasmyth-Miller, Jules Hernández-Sánchez, Stefan Sturm

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francisco BautistaPediatric Hematology, Oncology and Stem Cell Transplantation Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Dan EngelhardDepartment of Pediatrics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Carmelo RizzariPediatric Hematology-Oncology Unit, Department of Pediatrics, MBBM Foundation, ASST-Monza, University of Milano-Bicocca, Monza, Italy.
Margarita BakaDepartment of Pediatric Oncology, Aglaia Kyriakou Children's Hospital, Athens, Greece.
Jesús Saavedra-LozanoInfectious Disease Unit, Department of Pediatrics, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Eduardo Lopez-MedinaDepartment of Pediatrics, Universidad del Valle, Centro Médico Imbanaco and Centro de Estudios en Infectología Pediátrica, Cali, Colombia.
Clare Nasmyth-MillerRoche Products Ltd, Welwyn Garden City, UK.
Jules Hernández-SánchezRoche Products Ltd, Welwyn Garden City, UK.
Stefan SturmRoche Innovation Center Basel, Roche Pharmaceutical Research and Early Development, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This randomized phase 1b study evaluated the pharmacokinetics/pharmacodynamics of conventional-dose (30-75 mg twice daily [BID]) vs triple-dose (90-225 mg BID; weight-adjusted) oseltamivir for treatment of influenza in severely immunocompromised children <13 years. Oseltamivir carboxylate (OC) C

Indexed as

childrenclinical trialimmunocompromisedinfluenzaoseltamivir

Identifiers

PMID31660381
PMCPMC6809794

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.