Evidence map›Paper›PMID 31660345›Full record

ArticleOpen forum infectious diseases2019

Maintenance Immunosuppression Is Associated With Better Outcome in the 2017/2018 Influenza Epidemic.

Klaus Stahl, Benjamin Seeliger, Markus Busch, Olaf Wiesner, Tobias Welte, Matthias Eder, Andreas Schäfer, Johann Bauersachs, Hermann Haller, Albert Heim and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Klaus StahlDepartment of Gastroenterology, Hepatology and Endocrinology Hannover Medical School, Hannover, Germany.
Benjamin SeeligerDepartment of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Markus BuschDepartment of Gastroenterology, Hepatology and Endocrinology Hannover Medical School, Hannover, Germany.
Olaf WiesnerDepartment of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Tobias WelteDepartment of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Matthias EderDepartment of Hematology, Haemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
Andreas SchäferInstitute of Virology, Hannover Medical School, Hannover, Germany.
Johann BauersachsInstitute of Virology, Hannover Medical School, Hannover, Germany.
Hermann HallerDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
Albert HeimDepartment of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.
Marius M HoeperDepartment of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Sascha DavidDepartment of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of immunosuppression on outcomes in influenza is insufficiently understood. We analyzed the morbidity and mortality of immunocompetent (IC) vs immunosuppressed (IS) patients with influenza A and B in the 2017/2018 season.

methodsPatients with proven influenza in a German tertiary care hospital were analyzed for hospitalization, intensive care unit (ICU) admission, and mortality. Causes for IS were organ and bone marrow transplantation, AIDS, chemotherapy, and medical immunosuppression.

resultsIn total, 227 patients were included in this analysis (IC, n = 118 [52%]; IS, n = 109 [48%]). Hospitalization (71% vs 91%;

conclusionsWe observed that IS was not associated with a worse outcome in this influenza cohort. Due to the presence of both confounding and referral and selection bias, the conclusion that immunosuppression reduces mortality cannot be drawn. Prospective studies investigating the influence of baseline immunosuppression on severity of influenza infection are desirable.

Indexed as

cardiomyopathyextracorporeal life supportimmunosuppressioninfluenzasepsis

Identifiers

PMID31660345
PMCPMC6785702

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