Evidence map›Paper›PMID 31660343›Full record

ArticleOpen forum infectious diseases2019

Fecal Transplant in Children With

Suchitra K Hourigan, Michelle Ahn, Keylie M Gibson, Marcos Pérez-Losada, Grace Felix, Melissa Weidner, Ian Leibowitz, John E Niederhuber, Cynthia L Sears, Keith A Crandall and 1 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Rational Design of Live Biotherapeutic Products for the Prevention ofbioRxiv : the preprint server for biology · 2024
    Article
  10. Vaccination to Reduce Antimicrobial Resistance Burden-Data Gaps and Future Research.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  11. Article
  12. Article
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Suchitra K HouriganInova Translational Medicine Institute, Falls Church, Virginia.ORCID 0000-0003-2656-5694
Michelle AhnComputational Biology Institute and, Washington, DC.
Keylie M GibsonComputational Biology Institute and, Washington, DC.
Marcos Pérez-LosadaComputational Biology Institute and, Washington, DC.
Grace FelixPediatric Specialists of Virginia, Fairfax, Virginia.
Melissa WeidnerJohns Hopkins University School of Medicine, Baltimore, Maryland.
Ian LeibowitzPediatric Specialists of Virginia, Fairfax, Virginia.
John E NiederhuberInova Translational Medicine Institute, Falls Church, Virginia.
Cynthia L SearsJohns Hopkins University School of Medicine, Baltimore, Maryland.
Keith A CrandallComputational Biology Institute and, Washington, DC.
Maria Oliva-HemkerJohns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USMilken Institute · USBoston Children's Hospital · USVirginia Cancer Specialists · US

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Clinical and Translational Science Institute at Childrens National-Mentored Career Development CoreKL2TR001877 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI LUBAN, NAOMI L · 2016 to 2020
$2.0M
NCATS NIH HHS KL2 TR001877NCATS NIH HHS UL1 TR001876
6 · The paper itself

Abstract

backgroundFecal microbiota transplantation (FMT) treats

methodsNine children with recurrent CDI underwent FMT. Stool was collected from donor and recipient pre-FMT and longitudinally post-FMT for up to 24 weeks. Shotgun metagenomic sequencing was performed. Reads were analyzed using PathoScope 2.0.

resultsAll children had resolution of CDI. AMR genes decreased post-FMT (

conclusionsFMT for CDI in children decreases AMR genes and potential pathogens and changes microbiota composition and function. However, acquisition of certain AMR genes post-FMT combined with low levels of potential pathogens found in donors suggests that further study is warranted regarding screening donors using metagenomics sequencing before FMT.

Indexed as

antimicrobial resistancechildrenClostridioides difficileClostridium difficilefecal transplantpathogen

Identifiers

PMID31660343
PMCPMC6790402
OpenAlexW2970983735

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.