Evidence map›Paper›PMID 31660340›Full record

ArticleOpen forum infectious diseases2019

Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy.

Alexandra Audemard-Verger, Jacques Gasnault, Maxime Faisant, Marie-Catherine Besse, Nicolas Martin-Silva, Mado Berra, Luc Fournier, Jonathan Boutemy, Gwenola Maigne, Hubert De Boysson and 5 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Alexandra Audemard-VergerDepartment of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
Jacques GasnaultDepartment of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
Maxime FaisantDepartment of Pathology, CHU de Caen, Caen, France.
Marie-Catherine BesseDepartment of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
Nicolas Martin-SilvaDepartment of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
Mado BerraDepartment of Neurology, CHU de Caen, Caen, France.
Luc FournierDepartment of Radiology, CHU de Caen, Caen, France.
Jonathan BoutemyDepartment of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
Gwenola MaigneDepartment of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
Hubert De BoyssonDepartment of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
Alexis RuetDepartment of Physical and Rehabilitation Medicine, CHU de Caen, Caen, France.
Astrid VabretDepartment of Virology, CHU de Caen, Caen, France.
Françoise ChaponDepartment of Pathology, CHU de Caen, Caen, France.
Guillaume Martin-BlondelDepartment of Infectious Diseases, CHU de Purpan, Toulouse, France.
Achille AoubaDepartment of Internal Medicine and Clinical Immunology, CHU de Caen, Caen, France.
Centre Hospitalier Universitaire de Caen · FRUniversité de Caen Normandie · FRHôpital Purpan · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1

Indexed as

immune checkpoint inhibitorJC virusnivolumabPD-1progressive multifocal leukoencephalopathy

Identifiers

PMID31660340
PMCPMC6767972
OpenAlexW2978813227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.