Evidence map›Paper›PMID 31660330›Full record

ArticleOpen forum infectious diseases2019

Care Continuum and Postdischarge Outcomes Among HIV-Infected Adults Admitted to the Hospital in Zambia.

Lottie Haachambwa, Nyakulira Kandiwo, Paul M Zulu, David Rutagwera, Elvin Geng, Charles B Holmes, Edford Sinkala, Cassidy W Claassen, Michael J Mugavero, Mwanza Wa Mwanza and 2 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Lottie HaachambwaDepartment of Medicine, University Teaching Hospital, Lusaka, Zambia.
Nyakulira KandiwoDepartment of Medicine, University Teaching Hospital, Lusaka, Zambia.
Paul M ZuluZambia National Public Health Institute, Lusaka, Zambia.
David RutagweraUniversity Teaching Hospital HIV AIDS Programme, Lusaka, Zambia.
Elvin GengDepartment of Medicine, University of California at San Francisco, San Francisco, California.
Charles B HolmesJohns Hopkins University, Baltimore, Maryland.
Edford SinkalaDepartment of Medicine, University Teaching Hospital, Lusaka, Zambia.
Cassidy W ClaassenDepartment of Medicine, University Teaching Hospital, Lusaka, Zambia.
Michael J MugaveroDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Mwanza Wa MwanzaCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Janet M TuranSchool of Public Health, University of Alabama at Birmingham, Birmingham, Alabama.
Michael J VinikoorSchool of Medicine, University of Zambia, Lusaka, Zambia.
University of Alabama at Birmingham · USUniversity of Zambia · ZMUniversity Teaching Hospital · ZMCenter for Global Health · USCentre for Infectious Disease Research in Zambia · ZMUniversity of California, San Francisco · USUniversity of Maryland, Baltimore · USZambia National Public Health Institute · ZM

Funding

Feasibility of an integrated intervention to reduce advanced HIV disease mortality among hospitalized adults in ZambiaR34MH121103 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VINIKOOR, MICHAEL JEFFREY · 2019 to 2023
$726k
Re-engagement at Discharge (Re-Charge): Improving post-hospital outcomes for HIV-infected adults in ZambiaR34MH122265 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI CLAASSEN, CASSIDY W., VINIKOOR, MICHAEL JEFFREY · 2021 to 2023
$594k
NIMH NIH HHS R34 MH121103NIMH NIH HHS R34 MH122265
6 · The paper itself

Abstract

backgroundWe characterized the extent of antiretroviral therapy (ART) experience and postdischarge mortality among hospitalized HIV-infected adults in Zambia.

methodsAt a central hospital with an opt-out HIV testing program, we enrolled HIV-infected adults (18+ years) admitted to internal medicine using a population-based sampling frame. Critically ill patients were excluded. Participants underwent a questionnaire regarding their HIV care history and CD4 count and viral load (VL) testing. We followed participants to 3 months after discharge. We analyzed prior awareness of HIV-positive status, antiretroviral therapy (ART) use, and VL suppression (VS; <1000 copies/mL). Using Cox proportional hazards regression, we assessed risk factors for mortality.

resultsAmong 1283 adults, HIV status was available for 1132 (88.2%), and 762 (67.3%) were HIV-positive. In the 239 who enrolled, the median age was 36 years, 59.7% were women, and the median CD4 count was 183 cells/mm

conclusionsMost HIV-related hospitalizations and deaths may now occur among ART-experienced vs -naïve individuals in Zambia. Development and evaluation of inpatient interventions are needed to mitigate the high risk of death in the postdischarge period.

Indexed as

Africacare continuumhealth systemsHIV infectionhospitalization

Identifiers

PMID31660330
PMCPMC6778319
OpenAlexW2958961844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.