ArticleJournal of clinical and translational science2019
The SMART IRB platform: A national resource for IRB review for multisite studies.
Article in Journal of clinical and translational science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Evaluation of the National Dental PBRN central IRB since its inception in 2014 until 2025.Journal of clinical and translational science · 2026Article
- Ten years of Central IRB review for an NIH-funded large clinical trial network by an academic IRB: The NIH StrokeNet experience.Journal of clinical and translational science · 2026Article
- Intraoperative nerve-specific fluorescence visualization in head and neck surgery: a Phase 1 trial.Nature communications · 2025Article
- Requirements and special considerations for drug trials with children across six jurisdictions: 2. Ethics review in the regulatory approval process.Frontiers in medicine · 2025Article
- Protocol for evaluation of iTEST, a novel blended intervention to enhance introspective accuracy in psychotic disorders.NPP - digital psychiatry and neuroscience · 2025Article
- IRB challenges in multisite studies: A case report and commentary from the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA).HRB open research · 2024Article
- Leveraging the Expertise of the CTSA Program to Increase the Impact and Efficiency of Clinical Trials.JAMA network open · 2023Article
- Areas of strength and opportunities for growth in translational science education and training: Results of a scoping review from the NCATS Education Branch.Clinical and translational science · 2023Article
- Implementation of single IRB review for multisite human subjects research: Persistent challenges and possible solutions.Journal of clinical and translational science · 2023Article
- Article
- Enhancing PCORnet Clinical Research Network data completeness by integrating multistate insurance claims with electronic health records in a cloud environment aligned with CMS security and privacy requirements.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- From paper to screen: regulatory and operational considerations for modernizing the informed consent process.Journal of clinical and translational science · 2022Article
- The IRB Reliance Exchange (IREx): A national web-based platform for operationalizing single IRB review.Journal of clinical and translational science · 2022Article
- Opportunities and challenges in translational science.Clinical and translational science · 2021Review
- Handoffs and transitions in critical care-understanding scalability: study protocol for a multicenter stepped wedge type 2 hybrid effectiveness-implementation trial.Implementation science : IS · 2021Article
- The status of central ethical reviewing and challenges regarding its introduction to non-interventional studies in Japan.Nagoya journal of medical science · 2021Article
- A CTSA One Health Alliance (COHA) survey of clinical trial infrastructure in North American veterinary institutions.BMC veterinary research · 2021Article
- Transdisciplinary Perspectives on Precision Medicine.Health equity · 2021Article
- IDeA States Pediatric Clinical Trials Network for Underserved and Rural Communities.Pediatrics · 2020Article
- Scale-up of the Accrual to Clinical Trials (ACT) network across the Clinical and Translational Science Award Consortium: a mixed-methods evaluation of the first 18 months.Journal of clinical and translational science · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Single institutional review board (IRB) review of multisite research increased in frequency over a decade ago with a proliferation of master IRB reliance agreements supporting statewide and regional consortia and disease- and population-specific networks. Although successful, the increasing number of agreements presented significant challenges and illuminated potential benefits of a single, nationwide agreement. Anticipated changes in federal regulations highlighted the need to systematize and simplify IRB reliance. To address these challenges, the NIH National Center for Advancing Translational Sciences funded a project to establish a national IRB reliance network that would support national adoption of single IRB (sIRB) review. The Streamlined, Multisite, Accelerated Resources for Trials (SMART) IRB Platform launched in July 2016 to facilitate dissemination, adoption, and implementation of a collaboratively developed master IRB reliance agreement and supportive tools and resources. More than 580 institutions have joined SMART IRB's Master Common Reciprocal Institutional Review Board Authorization Agreement and begun using the SMART IRB platform to support sIRB arrangements. Here, we describe the tenets of the agreement and operational benefits and challenges of its use. SMART IRB's early success affirms the utility of collaborative, flexible, and centralized approaches to supporting sIRB review while highlighting the need for further national harmonization.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.