ArticleJournal of orthopaedics
Should we use dabigatran or aspirin thromboprophylaxis in total hip and knee arthroplasty? A natural experiment.
Article in Journal of orthopaedics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Prevention of venous thromboembolism with aspirin following knee surgery: A systematic review and meta-analysis.EFORT open reviews · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite long clinical experience some authorities recommend against the use of aspirin for perioperative VTE prophylaxis and favour alternatives such as dabigatran. A change from Dabigatran to an Aspirin based protocol in a British district general hospital created the conditions of a natural experiment.
methodsWe conducted a single centre, retrospective study of 6-months using a dabigatran based protocol (THA n = 191, TKA n = 155) and 6-months using and aspirin based protocol (THA n = 165, TKA n = 136). Outcomes addressed include: VTE used, VTE events within 90-days, 30-day return to theatre (RTT) rates, and 90-day mortality.
resultsPre-intervention, the dabigatran prescription rate was 73% (n = 139) and 78% (n = 123) with aspirin prescription post-intervention in 67% (n = 110) and 70% (n = 90) for THA and TKA respectively. We found a similar VTE rate when comparing dabigatran and aspirin groups for THA (2.2% vs. 0%, p = 0.17) and TKA (0.64% vs. 0%, p = 0.32). Similarly, no difference in the RTT rate was seen for THA (0.7% vs.2.7%, p = 0.23) or TKA (1.6% vs. 3.2%, p = 0.38).
conclusionNo significant differences in safety were found comparing aspirin to dabigatran for VTE prophylaxis for lower limb arthroplasty which, has not been previously reported and represents significant cost saving implications.
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