Evidence map›Paper›PMID 31659912›Full record

ReviewAIDS research and human retroviruses2020

Mechanisms of Human Immunodeficiency Virus-Associated Lymphocyte Regulated Cell Death.

Ana C Paim, Andrew D Badley, Nathan W Cummins

Abstract readReview
In one paragraph

Review in AIDS research and human retroviruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. HIV Latency in Myeloid Cells: Challenges for a Cure.Pathogens (Basel, Switzerland) · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. [Immunological Causes of Oral Manifestations of HIV Infection: A Literature Review].Revista cientifica odontologica (Universidad Cientifica del Sur)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ana C PaimDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota.
Andrew D BadleyDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota.
Nathan W CumminsDivision of Infectious Diseases, Mayo Clinic, Rochester, Minnesota.

Funding

Prime shock and kill for HIV erradicationR01AI110173 · NIAID · MAYO CLINIC ROCHESTER · PI BADLEY, ANDREW D · 2014 to 2024
$6.9M
Evaluating the role of the novel apoptosis inhibitor TRAILshort, in maintaining HIV persistence.R01AI120698 · NIAID · MAYO CLINIC ROCHESTER · PI BADLEY, ANDREW D · 2015 to 2019
$2.5M
BCL2 family proteins promote HIV-1 persistenceR56AI145407 · NIAID · MAYO CLINIC ROCHESTER · PI CUMMINS, NATHAN WILLIAM · 2019 to 2019
$398k
NIAID NIH HHS R01 AI110173NIAID NIH HHS R01 AI120698NIAID NIH HHS R56 AI145407
6 · The paper itself

Abstract

Human immunodeficiency virus-1 (HIV-1) causes CD4 T cell depletion through a number of mechanisms, including programmed cell death pathways (both apoptotic and nonapoptotic). In the setting of HIV-1 infection, the enhanced lymphocyte cell death occurs as a consequence of complex interactions between the host immune system and viral factors, which are reviewed herein. On the other hand, the main challenge to HIV-1 eradication is the development of latent infection in a subset of long lived cells, including CD4

Indexed as

ApoptosisAutophagyCD4-Positive T-LymphocytesCell DeathHIV-1HIV InfectionsHost Microbial InteractionsHumansLymphocytesMacrophagesNecroptosisapoptosisautophagyhuman immunodeficiency virusnecroptosis

Identifiers

PMID31659912
PMCPMC7044792

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.