Evidence map›Paper›PMID 31659886›Full record

ArticleMolecules and cells2019

Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells.

Qian Xu, Zhihua Liu, Ling Guo, Rui Liu, Rulei Li, Xiang Chu, Jiajia Yang, Jia Luo, Faming Chen, Manjing Deng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules and cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

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  14. Study on the Mechanism of Qigu Capsule in Upregulating NF-Evidence-based complementary and alternative medicine : eCAM · 2021
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  16. Histone methyltransferase and drug resistance in cancers.Journal of experimental & clinical cancer research : CR · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Qian XuDepartment of Stomatology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, China.
Zhihua LiuDepartment of Stomatology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, China.
Ling GuoDepartment of Stomatology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, China.
Rui LiuDepartment of Stomatology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, China.
Rulei LiDepartment of Stomatology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, China.
Xiang ChuDepartment of Stomatology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, China.
Jiajia YangDepartment of Stomatology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, China.
Jia LuoDepartment of Stomatology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, China.
Faming ChenDepartment of Periodontology, School of Stomatology, Air Force Medical University, Xi'an 710032, China.
Manjing DengDepartment of Stomatology, Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing 400042, China.
Daping Hospital · CNArmy Medical University · CNChildren's Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is characterized by the loss of periodontal tissues, especially alveolar bone. Common therapies cannot satisfactorily recover lost alveolar bone. Periodontal ligament stem cells (PDLSCs) possess the capacity of self-renewal and multilineage differentiation and are likely to recover lost alveolar bone. In addition, periodontitis is accompanied by hypoxia, and hypoxia-inducible factor-1α (HIF-1α) is a master transcription factor in the response to hypoxia. Thus, we aimed to ascertain how hypoxia affects runt-related transcription factor 2 (RUNX2), a key osteogenic marker, in the osteogenesis of PDLSCs. In this study, we found that hypoxia enhanced the protein expression of HIF-1α, vascular endothelial growth factor (VEGF), and RUNX2

Indexed as

Gene Expression RegulationAlkaline PhosphataseCell DifferentiationCell HypoxiaCells, CulturedCore Binding Factor Alpha 1 SubunitHumansHypoxia-Inducible Factor 1, alpha SubunitOsteocalcinOsteogenesisPeriodontal LigamentRNA InterferenceStem CellsVascular Endothelial Growth Factor AAlkaline PhosphataseCore Binding Factor Alpha 1 SubunitHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitOsteocalcinVascular Endothelial Growth Factor Ahypoxiahypoxia-inducible factor-1αmesenchymal stromal cellsrunt-related transcription factor 2vascular endothelial growth factor

Identifiers

PMID31659886
PMCPMC6883976
OpenAlexW2984525527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.