ArticleAddiction (Abingdon, England)2020
Sibling comparisons elucidate the associations between educational attainment polygenic scores and alcohol, nicotine and cannabis.
Article in Addiction (Abingdon, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Genetics of OCD and Related Disorders; Searching for Shared Factors.Current topics in behavioral neurosciences · 2021Pooled it
- Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Disentangling heterogeneity in substance use disorder: Insights from genome-wide polygenic scores.Translational psychiatry · 2024Article
- The Collaborative Study on the Genetics of Alcoholism: Overview.Genes, brain, and behavior · 2023Review
- The collaborative study on the genetics of alcoholism: Genetics.Genes, brain, and behavior · 2023Review
- The production of within-family inequality: Insights and implications of integrating genetic data.PNAS nexus · 2023Article
- School performance and genetic propensities for educational attainment and depression in the etiology of self-harm: a Danish population-based study.Nordic journal of psychiatry · 2023Article
- Engineering Virtuous health habits using Emotion and Neurocognition: Flexibility for Lifestyle Optimization and Weight management (EVEN FLOW).Frontiers in aging neuroscience · 2023Review
- The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond.Translational psychiatry · 2022Review
- Article
Corrections and comments
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Authors and funding
19 authors at 10 institutions in 3 countries.
Funding
Abstract
BACKGROUND AND
aimsThe associations between low educational attainment and substance use disorders (SUDs) may be related to a common genetic vulnerability. We aimed to elucidate the associations between polygenic scores for educational attainment and clinical criterion counts for three SUDs (alcohol, nicotine and cannabis).
designPolygenic association and sibling comparison methods. The latter strengthens inferences in observational research by controlling for confounding factors that differ between families.
settingSix sites in the United States.
participantsEuropean ancestry participants aged 25 years and older from the Collaborative Study on the Genetics of Alcoholism (COGA). Polygenic association analyses included 5582 (54% female) participants. Sibling comparisons included 3098 (52% female) participants from 1226 sibling groups nested within the overall sample. MEASUREMENTS: Outcomes included criterion counts for DSM-5 alcohol use disorder (AUDSX), Fagerström nicotine dependence (NDSX) and DSM-5 cannabis use disorder (CUDSX). We derived polygenic scores for educational attainment (EduYears-GPS) using summary statistics from a large (> 1 million) genome-wide association study of educational attainment.
findingsIn polygenic association analyses, higher EduYears-GPS predicted lower AUDSX, NDSX and CUDSX [P < 0.01, effect sizes (R
conclusionsIndividuals who carry more alleles associated with educational attainment tend to meet fewer clinical criteria for alcohol, nicotine and cannabis use disorders, and these effects are robust to rigorous controls for potentially confounding factors that differ between families (e.g. socio-economic status, urban-rural residency and parental education).
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