Evidence map›Paper›PMID 31659792›Full record

ArticlePaediatric and perinatal epidemiology2019

The Preconception Period analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium.

Emily W Harville, Gita D Mishra, Edwina Yeung, Sunni L Mumford, Enrique F Schisterman, Anne Marie Jukic, Elizabeth E Hatch, Ellen M Mikkelsen, Hong Jiang, Deborah B Ehrenthal and 18 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatric and perinatal epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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  13. Large-Scale Data Harmonization Across Prospective Studies.American journal of epidemiology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 7 countries.

Emily W HarvilleDepartment of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, LA, USA.ORCID 0000-0003-0319-0922
Gita D MishraSchool of Public Health, University of Queensland, Herston, QLD, Australia.
Edwina YeungEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Sunni L MumfordEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.ORCID 0000-0003-0133-3176
Enrique F SchistermanEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
Anne Marie JukicEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA.
Elizabeth E HatchDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Ellen M MikkelsenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Hong JiangDepartment of Maternal, Child and Adolescent Health, School of Public Health, Key Laboratory of Public Health Safety (Ministry of Education), Global Health Institute, Fudan University, Shanghai Shi, China.
Deborah B EhrenthalDepartment of Population Health Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Christina A PorucznikDivision of Public Health, Department of Family and Preventive Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
Joseph B StanfordDivision of Public Health, Department of Family and Preventive Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-9932-3947
Shi-Wu WenOMNI Research Group, Department of Obstetrics & Gynecology, University of Ottawa, Faculty of Medicine, Ottawa, ON, Canada.
Alysha HarveyOMNI Research Group, Department of Obstetrics & Gynecology, University of Ottawa, Faculty of Medicine, Ottawa, ON, Canada.
Danielle Symons DownsDepartment of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, PA, USA.
Chittaranjan YajnikDiabetes Unit, King Edward Memorial Hospital & Research Centre, Pune, India.
Donna SantillanDepartment of Obstetrics and Gynecology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Mark SantillanDepartment of Obstetrics and Gynecology, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.
Thomas F McElrathDepartment of Obstetrics and Gynecology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Jessica G WooDepartment of Pediatrics, Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
Elaine M UrbinaDepartment of Pediatrics, Heart Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
Jorge E ChavarroDepartment of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Daniela Sotres-AlvarezDepartment of Biostatistics, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Lydia BazzanoDepartment of Epidemiology, Tulane School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Jun ZhangMinistry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-1706-1611
Anne SteinerDuke University Hospital, Durham, NC, USA.
Erica P GundersonDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USBoston University · USCincinnati Children's Hospital Medical Center · USTulane University · USUniversity of Iowa Hospitals and Clinics · USUniversity of Ottawa · CAUniversity of Utah · USAarhus University Hospital · DKBrigham and Women's Hospital · USDuke University Hospital · USFudan University · CNKaiser Permanente · USKing Edward Memorial Hospital Research Centre · INMassachusetts Department of Public Health · USNational Institute of Environmental Health Sciences · USPennsylvania State University · USShanghai Jiao Tong University · CNThe University of Queensland · AUUniversity of North Carolina at Chapel Hill · USUniversity of Wisconsin–Madison · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Peri-Conceptional BiomonitoringR01ES020488 · NIEHS · UNIVERSITY OF UTAH · PI PORUCZNIK, CHRISTINA · 2011 to 2015
$2.1M
Clinical Research in Human FertilityK23HD001479 · NICHD · UNIVERSITY OF UTAH · PI STANFORD, JOSEPH B · 2001 to 2005
$673k
NCATS NIH HHS UL1 TR001863NICHD NIH HHS K23 HD001479NIEHS NIH HHS R01 ES020488NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

backgroundPreconception health may have intergenerational influences. We have formed the PrePARED (Preconception Period Analysis of Risks and Exposures influencing health and Development) research consortium to address methodological, conceptual, and generalisability gaps in the literature.

objectivesThe consortium will investigate the effects of preconception exposures on four sets of outcomes: (1) fertility and miscarriage; (2) pregnancy-related conditions; (3) perinatal and child health; and (4) adult health outcomes. POPULATION: A study is eligible if it has data measured for at least one preconception time point, has a minimum of selected core data, and is open to collaboration and data harmonisation.

designThe included studies are a mix of studies following women or couples intending to conceive, general-health cohorts that cover the reproductive years, and pregnancy/child cohort studies that have been linked with preconception data. The majority of the participating studies are prospective cohorts, but a few are clinical trials or record linkages.

methodsData analysis will begin with harmonisation of data collected across cohorts. Initial areas of interest include nutrition and obesity; tobacco, marijuana, and other substance use; and cardiovascular risk factors. PRELIMINARY

resultsTwenty-three cohorts with data on almost 200 000 women have combined to form this consortium, begun in 2018. Twelve studies are of women or couples actively planning pregnancy, and six are general-population cohorts that cover the reproductive years; the remainder have some other design. The primary focus for four was cardiovascular health, eight was fertility, one was environmental exposures, three was child health, and the remainder general women's health. Among other cohorts assessed for inclusion, the most common reason for ineligibility was lack of prospectively collected preconception data.

conclusionsThe consortium will serve as a resource for research in many subject areas related to preconception health, with implications for science, practice, and policy.

Indexed as

Preconception CareResearch DesignAdultBiomedical ResearchChild HealthFemaleHumansInfant HealthInfertilityIntersectoral CollaborationMaleMaternal ExposurePaternal ExposurePregnancyPregnancy ComplicationsPrenatal Exposure Delayed Effectsbirthweightcohort studiescommon data elementsfertilitypreconception carepregnancyresearch design

Identifiers

PMID31659792
PMCPMC6901022
OpenAlexW2982532909

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.