Evidence map›Paper›PMID 31659786›Full record

ArticleStatistics in medicine2019

Covariate-adjusted region-referenced generalized functional linear model for EEG data.

Aaron W Scheffler, Donatello Telesca, Catherine A Sugar, Shafali Jeste, Abigail Dickinson, Charlotte DiStefano, Damla Şentürk

Abstract read
In one paragraph

Article in Statistics in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Contrastive Latent Functional Model.Statistics in biosciences · 2026
    Article
  2. Article
  3. Article
  4. Covariate Adjusted Functional Mixed Membership Models.Statistics and data science in imaging · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Functional Mixed Membership Models.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2024
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aaron W SchefflerDepartment of Biostatistics, University of California, Los Angeles, California.
Donatello TelescaDepartment of Biostatistics, University of California, Los Angeles, California.
Catherine A SugarDepartment of Biostatistics, University of California, Los Angeles, California.
Shafali JesteDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California.
Abigail DickinsonDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California.
Charlotte DiStefanoDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California.
Damla ŞentürkDepartment of Biostatistics, University of California, Los Angeles, California.ORCID 0000-0002-7619-5428

Funding

UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5M
A unified longitudinal functional data framework for the analysis of complex biomedical dataR01GM111378 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SENTURK, DAMLA, SUGAR, CATHERINE ANN · 2015 to 2018
$1.4M
NICHD NIH HHS U54 HD087101NIGMS NIH HHS R01 GM111378
6 · The paper itself

Abstract

Electroencephalography (EEG) studies produce region-referenced functional data in the form of EEG signals recorded across electrodes on the scalp. It is of clinical interest to relate the highly structured EEG data to scalar outcomes such as diagnostic status. In our motivating study, resting-state EEG is collected on both typically developing (TD) children and children with autism spectrum disorder (ASD) aged 2 to 12 years old. The peak alpha frequency (PAF), defined as the location of a prominent peak in the alpha frequency band of the spectral density, is an important biomarker linked to neurodevelopment and is known to shift from lower to higher frequencies as children age. To retain the most amount of information from the data, we consider the oscillations in the spectral density within the alpha band, rather than just the peak location, as a functional predictor of diagnostic status (TD vs ASD), adjusted for chronological age. A covariate-adjusted region-referenced generalized functional linear model is proposed for modeling scalar outcomes from region-referenced functional predictors, which utilizes a tensor basis formed from one-dimensional discrete and continuous bases to estimate functional effects across a discrete regional domain while simultaneously adjusting for additional nonfunctional covariates, such as age. The proposed methodology provides novel insights into differences in neural development of TD and ASD children. The efficacy of the proposed methodology is investigated through extensive simulation studies.

Indexed as

Alpha RhythmAutism Spectrum DisorderBiostatisticsCase-Control StudiesChildChild DevelopmentChild, PreschoolComputer SimulationElectroencephalographyHumansLinear ModelsModels, NeurologicalMonte Carlo Methodautism spectrum disorderelectroencephalographyfunctional data analysispeak alpha frequencypenalized regression

Identifiers

PMID31659786
PMCPMC6891124

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.