Evidence map›Paper›PMID 31659595›Full record

Trial reportJournal of autism and developmental disorders2020

Gluten-Free Diet in Children with Autism Spectrum Disorders: A Randomized, Controlled, Single-Blinded Trial.

Anna Piwowarczyk, Andrea Horvath, Ewa Pisula, Rafał Kawa, Hania Szajewska

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of autism and developmental disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02280746 (Gluten Dietary Intervention for Autistic Symptoms in Children With Autism Spectrum Disorders - Randomized Open Trial), which is not on this map. Cited by 31 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02280746 naunknown statusnot on this map

Gluten Dietary Intervention for Autistic Symptoms in Children With Autism Spectrum Disorders - Randomized Open Trial

TypeinterventionalSponsorMedical University of WarsawRan2014 to 2015Enrolled70ConditionsAutism Spectrum DisordersArmsGluten challenge
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Complementary and Alternative Medicine for Autism - A Systematic Review.Journal of autism and developmental disorders · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna PiwowarczykDepartment of Paediatrics with Clinical Assessment Unit, The Medical University of Warsaw, Zwirki i Wigury 63a, 02-091, Warsaw, Poland.
Andrea HorvathDepartment of Paediatrics, The Medical University of Warsaw, Zwirki i Wigury 63A, 02-091, Warsaw, Poland.
Ewa PisulaDepartment of Health and Rehabilitation Psychology, Faculty of Psychology, University of Warsaw, Stawki 5/7, 00-183, Warsaw, Poland.
Rafał KawaDepartment of Health and Rehabilitation Psychology, Faculty of Psychology, University of Warsaw, Stawki 5/7, 00-183, Warsaw, Poland.
Hania SzajewskaDepartment of Paediatrics, The Medical University of Warsaw, Zwirki i Wigury 63A, 02-091, Warsaw, Poland. hania@ipgate.pl.

Funding

Nutricia Foundation Research grant [RG8/2013]
6 · The paper itself

Abstract

To determine whether a gluten-free diet (GFD) compared with a gluten-containing diet (GD) influences functioning of children with autism spectrum disorders (ASD), we performed a randomized, controlled, single-blinded trial. Sixty-six children (36-69 months) with ASD, within the normal IQ (> 70) range, who had been on a GFD for at least 8 weeks before enrollment were eligible for inclusion. After an 8-week run-in period on a GFD, the GFD group continued this diet and the GD group consumed at least one normal meal containing gluten per day for 6 months. There were no differences between groups in autistic symptoms, maladaptive behaviors, or intellectual abilities after the intervention. A GFD compared with a GD did not affect functioning of children with ASD.Trial registration ClinicalTrials.gov, number NCT02280746.

Indexed as

Autism Spectrum DisorderChild, PreschoolDiet, Gluten-FreeFemaleHumansMaleAutism spectrum disorderChildrenGlutenRandomized controlled trial

Identifiers

PMID31659595

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.