ArticleGeroScience2019
Age-related compositional and functional changes in micro-pig gut microbiome.
Article in GeroScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed.
- A manually curated pig gut microbiome dataset for precision feeding.Scientific data · 2026Article
- A Pilot Study on the Effects of Sweet Potato Petiole and Leaf Powder on Gut Microbiota and Aging-Related Biomarkers in an Aged Microminipig Model.Metabolites · 2025Article
- Integrating Machine Learning to Identify Key Microbiota of Gut Community Changes Across Different Stages in Dahe Black Pigs.Microorganisms · 2025Article
- Gut microbiota variations over the lifespan and longevity in rabbit's maternal lines.Scientific reports · 2025Article
- Range-Wide Assessment of the Tasmanian Devil Gut Microbiome.Ecology and evolution · 2025Article
- Microbiota Analysis and Characterisation of the NovelMicroorganisms · 2025Article
- Characterization of microbiota signatures in Iberian pig strains using machine learning algorithms.Animal microbiome · 2025Article
- Contributions and future potential of animal models for geroscience research on sensory systems.GeroScience · 2025Review
- Evaluation of energy and nutrient utilization for corn, barley, and wheat bran in primiparous and multiparous sows during the gestation, lactation, and post-weaning period.Journal of animal science · 2025Article
- Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages.GeroScience · 2024Review
- Shaping the tripartite symbiosis: are termite microbiome functions directed by the environmentally acquired fungal cultivar?Animal microbiome · 2024Article
- The pig as an optimal animal model for cardiovascular research.Lab animal · 2024Review
- A comparative study of the bacterial diversity and composition of nursery piglets' oral fluid, feces, and housing environment.Scientific reports · 2024Article
- The impact of host genetics on porcine gut microbiota composition excluding maternal and postnatal environmental influences.PloS one · 2024Article
- Age-related compositional and functional changes in the adult and breastfed buffalo rumen microbiome.Frontiers in microbiology · 2024Article
- Unique trans-kingdom microbiome structural and functional signatures predict cognitive decline in older adults.GeroScience · 2023Article
- Cefquinome shows a higher impact on the pig gut microbiome and resistome compared to ceftiofur.Veterinary research · 2023Article
- Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator.International journal of environmental research and public health · 2023Review
- Discrete patterns of microbiome variability across timescales in a wild rodent population.BMC microbiology · 2023Article
- Dietary Supplementation with Botanical Blends Modified Intestinal Microbiota and Metabolomics of Weaned Pigs Experimentally Infected with EnterotoxigenicMicroorganisms · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related changes in human gut microbiota composition have been reported, and such changes might be influenced by the intake of nutrients or diets. To investigate the effects of aging on the gut microbiota independent of nutrient effects, we analyzed the gut microbiomes of 126 micro-pigs at a wide range of ages from newborns to 10 years old. The micro-pigs were reared in a constantly controlled environment. The diversity of the gut microbiome was found to continuously change with age. We also found associations between age and specific members and functions of the gut microbiome. Consistent with previous studies on the human gut microbiome, beneficial microbes including probiotic bacteria and short-chain fatty acid-producers decreased in older pigs, whereas Bacteroides increased with age. Based on the correlation network, Bacteroides seemed to have an important role in determining the relative abundances of other beneficial microbes. Our results suggest that maintaining beneficial gut microbes at a specific ratio corresponding to a certain age might contribute to a younger gut microbiome-age. Furthermore, due to similarities with the human system, micro-pigs are a useful animal model to elucidate the links between aging and the microbiome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.