ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2020
Distribution and relevance of Dientamoeba fragilis and Blastocystis species in gastroenteritis: results from a case-control study.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Molecular epidemiology and genotype diversity of Dientamoeba fragilis in a Czech hospital-based cohort: higher prevalence in paediatric patients and evidence of mixed G1/G2 infection in a single patient.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Molecular epidemiology of Dientamoeba fragilis coinfections with Blastocystis sp. and Giardia duodenalis in symptomatic patients from Valencia, Spain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Quantitative detection of gut microbial eukaryotes with EukDetect2 reveals global distribution of commensal protists and association with distinct microbial community structure.bioRxiv : the preprint server for biology · 2026Article
- Fecal Microbiota Transplantation Donor Screening: IsMicroorganisms · 2026Article
- First detection and molecular characterization of three trichomonad species in experimental beagle dogs in China.Parasite (Paris, France) · 2026Article
- Review
- Molecular Investigation and Characterization of Enterocytozoon bieneusi, Coxiella burnetii and Dientamoeba fragilis in Raw Milk and Cheese: A First Report for Dientamoeba fragilis.Acta parasitologica · 2025Article
- Evolution and ecology of commensal gut protists: recent advances.Current opinion in genetics & development · 2025Review
- Improvement of the diagnosis of intestinal protozoa using a multiplex qPCR strategy compared to classical microscopy: a prospective study on 3,500 stool samples over 3 years.Journal of clinical microbiology · 2025Article
- Observational
- Blastocystis hominis; Friend or Foe.Integrative medicine (Encinitas, Calif.) · 2024Review
- No evidence of pathogenicity of Dientamoeba fragilis following detection in stools: A case-control study.Parasite (Paris, France) · 2024Article
- Molecular prevalence and subtype distribution of Blastocystis spp. among children who have diarrheia or are asymptomatic in Wenzhou, Zhejiang Province, China.Parasite (Paris, France) · 2024Article
- Diabetes and gut microbiome.Frontiers in microbiology · 2024Review
- Prevalence of Blastocystis and Dientamoeba fragilis in diarrheal patients in Corum, Türkiye.Parasitology research · 2023Article
- Treatment ofNew microbes and new infections · 2023Article
- Evaluation of the Performance of the NovodiagPathogens (Basel, Switzerland) · 2023Article
- Circulation and colonisation ofEpidemiology and infection · 2023Article
- A Cross-Sectional Study on the Occurrence of the Intestinal Protist,International journal of molecular sciences · 2022Article
- Individuals with Inflammatory Bowel Disease Have an Altered Gut Microbiome Composition of Fungi and Protozoa.Microorganisms · 2022Article
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Authors and funding
7 authors.
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Abstract
The actual role of Dientamoeba fragilis and Blastocystis in patients with gastrointestinal symptoms is still under debate. A multicenter case-control study was performed in The Netherlands to elucidate the clinical relevance of molecular diagnostics results in gastroenteritis (GE). Samples from this case-control study were used to perform a detailed analysis on the presence of D. fragilis and Blastocystis in relation to gastrointestinal symptoms. In the present study, a real-time PCR for Blastocystis was performed on 1374 case samples and 1026 control samples from the multicenter gastroenteritis case-control study previously tested for D. fragilis. Prevalence of both micro-organisms was highest in children under 20 years of age and lowest in the oldest age group. A significantly lower overall detection of D. fragilis and Blastocystis was found in cases (both 25.8%) as compared to controls (37.6% and 40.0%, respectively). The difference for D. fragilis was statistically significant for subjects above 20 years of age. For Blastocystis, the difference was statistically significant in all age groups, except in children less than 5 years of age. A negative relation between D. fragilis-positive cases and diarrhea was found in this study population. More GE symptoms were reported in cases without D. fragilis or Blastocystis. In the present study, prevalence of both D. fragilis and Blastocystis is lower in cases with gastroenteritic symptoms than in controls. Besides, in cases with D. fragilis or Blastocystis, no association is shown between any of the GE symptoms. Interestingly, this suggests that the presence of these protozoans may be considered characteristic of a healthy intestinal microbiome.
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